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Details on Person PSEN1 [plasma membrane]

Class:Id	Complex:2534316
_displayName	PSEN1 [plasma membrane]
_timestamp	2017-07-24 14:11:55
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2534268] Jupe, S, 2012-10-24
hasComponent	[EntityWithAccessionedSequence:2534245] PSEN1(299-467) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:2534298] PSEN1(1-298) [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:2534295] Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue [LiteratureReference:9013341] Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop? [LiteratureReference:9013338] Structural investigation of the C-terminal catalytic fragment of presenilin 1 [LiteratureReference:9013342] Therapeutic modulation of Notch signalling--are we there yet?
modified	[InstanceEdit:9013355] Orlic-Milacic, Marija, 2017-07-24
name	PSEN1 PS1 Presenillin-1 PSEN1 dimer
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4546133] R-HSA-2534316.2
(hasComponent)	[Complex:2534270] PS1:NCSTN [plasma membrane] [Homo sapiens]
(hasMember)	[DefinedSet:2537541] PS1, Caspase-3 [cytosol] [Homo sapiens] [DefinedSet:9013333] Presenilin [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9897727] Update Tracker - [Complex:2534316] PSEN1 [plasma membrane] - v62:[addLiteratureReference, addName]
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No pathways have been reviewed or authored by PSEN1 [plasma membrane] (2534316)