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Details on Person The majority of aggrecan fragments present in synovial fluid...

Class:Id	Summation:2533991
_displayName	The majority of aggrecan fragments present in synovial fluid...
_timestamp	2013-08-16 07:41:03
created	[InstanceEdit:2533987] Jupe, S, 2012-10-22
literatureReference	[LiteratureReference:3791309] The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain [LiteratureReference:3791326] Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family [LiteratureReference:3791258] Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins [LiteratureReference:3791324] Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4
modified	[InstanceEdit:2984194] Jupe, S, 2013-01-15 [InstanceEdit:3791337] Jupe, S, 2013-07-05 [InstanceEdit:4224009] Jupe, S, 2013-08-16
text	The majority of aggrecan fragments present in synovial fluid of OA patients are cleaved at Glu392-Ala393 (numbered here according to the human UniProt sequence, these residues referred to as Glu373-Ala374 in most literature) in the IGD (Sandy et al. 1992). ADAMTS5 (aggrecanase-2, Abbaszade et al. 1999) and to a lesser extent ADAMTS4 (aggrecanase-1, Tortorella et al. 1999) are primarrily responsible (Gendron et al. 2007).
(summation)	[Reaction:2533988] Aggrecan degradation by ADAMTS4,ADAMTS5 [Bos taurus]
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