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Details on Person Aggrecan degradation by ADAMTS4,ADAMTS5

Class:Id	Reaction:2533988
_displayName	Aggrecan degradation by ADAMTS4,ADAMTS5
_doRelease	TRUE
_timestamp	2013-09-05 11:45:47
authored	[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity	[CatalystActivity:3791158] metalloendopeptidase activity of ADAMTS4, 5, (1, 8, 9, 16, 18) [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:2533987] Jupe, S, 2012-10-22
edited	[InstanceEdit:4090280] Jupe, S, 2013-08-13
input	[EntityWithAccessionedSequence:2533993] ACAN [extracellular region] [Bos taurus]
isChimeric	TRUE
literatureReference	[LiteratureReference:3791324] Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4 [LiteratureReference:3791310] ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors [LiteratureReference:3791288] Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1 [LiteratureReference:3791306] ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage [LiteratureReference:3791307] Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18
modified	[InstanceEdit:2984194] Jupe, S, 2013-01-15 [InstanceEdit:3791165] Jupe, S, 2013-07-05 [InstanceEdit:3791337] Jupe, S, 2013-07-05 [InstanceEdit:4093350] Jupe, S, 2013-08-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Aggrecan degradation by ADAMTS4,ADAMTS5
output	[EntityWithAccessionedSequence:2533984] ACAN N-term fragment [extracellular region] [Bos taurus] [EntityWithAccessionedSequence:2533980] ACAN C-term fragment [extracellular region] [Bos taurus]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48898] Bos taurus [Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545180] R-NUL-2533988.2
summation	[Summation:2533991] The majority of aggrecan fragments present in synovial fluid...
(inferredFrom)	[Reaction:1592310] Aggrecan degradation by ADAMTSs [Homo sapiens]
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No pathways have been reviewed or authored by Aggrecan degradation by ADAMTS4,ADAMTS5 (2533988)