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Details on Person UniProt:Q9DBA6 Tysnd1
| Class:Id | ReferenceGeneProduct:253234 |
|---|---|
| _chainChangeLog | chain:1-568 added on Fri February 6 2015;chain:1-110 added on Fri February 6 2015;chain:111-568 added on Fri February 6 2015 |
| _displayName | UniProt:Q9DBA6 Tysnd1 |
| _timestamp | 2023-11-03 18:36:22 |
| chain | chain:1-568 chain:1-110 chain:111-568 |
| checksum | B7BED91B4DB50E5E |
| comment | FUNCTION Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids (By similarity).ACTIVITY REGULATION Inhibited by N-ethylmaleimide (NEM). Not affected by leupeptin or trans-epoxysuccinyl-l-leucylamido-(4-gianidino) butane (E64).SUBUNIT Homodimer. Forms a heterodimer with the C-terminal cleavage product (49 kDa form). Forms a heterodimer with the N-terminal cleavage product (10 kDa form). Interacts with PEX5. Interacts with LONP2.SUBCELLULAR LOCATION By the proliferator-activated receptor alpha agonist bezafibrate.PTM Self-cleavage gives rise to an N-terminal 10-kDa fragment and C-terminal 49-kDa fragment upon import into the peroxisomes. The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.SIMILARITY Belongs to the peptidase S1B family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Peroxisomal leader peptide-processing protease ecNumber: 3.4.21.- alternativeName: Trypsin domain-containing protein 1 component recommendedName: Peroxisomal leader peptide-processing protease, 10 kDa form /component component recommendedName: Peroxisomal leader peptide-processing protease, 49 kDa form /component |
| geneName | Tysnd1 |
| identifier | Q9DBA6 |
| isSequenceChanged | FALSE |
| keyword | Direct protein sequencing Hydrolase Peroxisome Protease Reference proteome Serine protease |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Tysnd1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TYSD1_MOUSE Q0VE90 |
| sequenceLength | 568 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9033991] Tysnd1 [peroxisomal matrix] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q9DBA6 Tysnd1 (253234)
