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Details on Person UniProt:Q2T9J0 TYSND1
| Class:Id | ReferenceGeneProduct:253232 |
|---|---|
| _chainChangeLog | chain:1-566 added on Sat February 7 2015;chain:1-110 added on Sat February 7 2015;chain:111-566 added on Sat February 7 2015 |
| _displayName | UniProt:Q2T9J0 TYSND1 |
| _timestamp | 2024-11-03 19:49:20 |
| chain | chain:1-566 chain:1-110 chain:111-566 |
| checksum | 530B895B8698F2E6 |
| comment | FUNCTION Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.SUBUNIT Homodimer. Forms a heterodimer with the C-terminal cleavage product (45 kDa form). Forms a heterodimer with the N-terminal cleavage product (15 kDa form). Interacts with PEX5. Interacts with LONP2.INTERACTION Self-cleavage gives rise to an N-terminal 15-kDa fragment and C-terminal 45-kDa fragment upon import into the peroxisomes. The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.SIMILARITY Belongs to the peptidase S1B family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Peroxisomal leader peptide-processing protease ecNumber: 3.4.21.- alternativeName: Trypsin domain-containing protein 1 component recommendedName: Peroxisomal leader peptide-processing protease, 15 kDa form /component component recommendedName: Peroxisomal leader peptide-processing protease, 45 kDa form /component |
| geneName | TYSND1 |
| identifier | Q2T9J0 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Hydrolase Peroxisome Protease Proteomics identification Reference proteome Serine protease |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TYSND1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000932] ENSEMBL:ENSG00000156521 TYSND1 [Homo sapiens] |
| secondaryIdentifier | TYSD1_HUMAN Q5SQT4 Q5SQU1 Q8N6H2 Q96AR5 |
| sequenceLength | 566 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:253233] UniProt:Q2T9J0-2 TYSND1 [Homo sapiens] [ReferenceIsoform:406291] UniProt:Q2T9J0-1 TYSND1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8933309] TYSND1 [peroxisomal matrix] [Homo sapiens] [EntityWithAccessionedSequence:9033586] TYSND1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9033587] TYSND1(1-110) [peroxisomal matrix] [Homo sapiens] [EntityWithAccessionedSequence:9033589] TYSND1(111-566) [peroxisomal matrix] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q2T9J0 TYSND1 (253232)
