Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q6IBS0 TWF2
| Class:Id | ReferenceGeneProduct:253145 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-349 added on Fri February 6 2015;initiator methionine:1 for 253145 removed on Fri Nov 03 2023;initiator methionine: for 253145 added on Fri Nov 03 2023;initiator methionine: for 253145 removed on Fri Aug 15 2025;initiator methionine:1 for 253145 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q6IBS0 TWF2 |
| _timestamp | 2025-08-15 21:42:28 |
| chain | initiator methionine:1 chain:2-349 |
| checksum | 635EF8C04EFCE92B |
| comment | FUNCTION Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).SUBUNIT Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF1 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated. Interacts with MYO7A (By similarity).INTERACTION Perinuclear and G-actin-rich cortical actin structure sublocalization.TISSUE SPECIFICITY Ubiquitously expressed (at protein level).PTM In vitro, phosphorylated by PRKCZ, CK2 and SRC.SIMILARITY Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.ONLINE INFORMATION Molecular embrace - Issue 73 of August 2006 |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Twinfilin-2 alternativeName: A6-related protein shortName: hA6RP alternativeName: Protein tyrosine kinase 9-like alternativeName: Twinfilin-1-like protein |
| geneName | TWF2 PTK9L MSTP011 |
| identifier | Q6IBS0 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin-binding Cell projection Cilium biogenesis/degradation Cytoplasm Cytoskeleton Direct protein sequencing Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TWF2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991635] ENSEMBL:ENSG00000247596 TWF2 [Homo sapiens] |
| secondaryIdentifier | TWF2_HUMAN Q9Y3F5 |
| sequenceLength | 349 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9663291] TWF2 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q6IBS0 TWF2 (253145)
