Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q16881-5 TXNRD1
| Class:Id | ReferenceIsoform:252810 |
|---|---|
| _chainChangeLog | chain:1-649 added on Fri February 6 2015 |
| _displayName | UniProt:Q16881-5 TXNRD1 |
| _timestamp | 2026-02-20 22:39:38 |
| chain | chain:1-649 |
| checksum | 5A51C3F77EB03EFE |
| comment | FUNCTION Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. A selenocysteine residue at the C-terminal active site is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437).FUNCTION Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions.FUNCTION Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2.FUNCTION Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063). Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665).CATALYTIC ACTIVITY [thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)CATALYTIC ACTIVITY H2O2 + NADPH + H(+) = NADP(+) + 2 H2OCOFACTOR Binds 1 FAD per subunit.BIOPHYSICOCHEMICAL PROPERTIES kcat is 100 min(-1) with H2O2 as substrate.SUBUNIT Homodimer (PubMed:17512005, PubMed:8577704). Interacts with HERC5.SUBUNIT Interacts with ESR1 and ESR2.INTERACTION Expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines.TISSUE SPECIFICITY Widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.INDUCTION Induced by estradiol or testosterone in HeLa cells.INDUCTION Induced by a combination of interferon-beta and retinoic acid (at protein level).DOMAIN The N-terminal glutaredoxin domain does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays.PTM The N-terminus is blocked.PTM ISGylated.MISCELLANEOUS The thioredoxin reductase active site is a redox-active disulfide bond. A C-terminal selenocysteine residue is essential for catalytic activity.MISCELLANEOUS Minor isoform.MISCELLANEOUS Major isoform. The N-terminus of the sequence is processed into a mature form that lacks residues Met-151 and Asn-152 at the N-terminus.SIMILARITY Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Truncated C-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="29"Thioredoxin reductase 1, cytoplasmic shortName: TR ecNumber evidence="14"1.8.1.9 alternativeName: Gene associated with retinoic and interferon-induced mortality 12 protein shortName: GRIM-12 shortName: Gene associated with retinoic and IFN-induced mortality 12 protein alternativeName: KM-102-derived reductase-like factor alternativeName: fullName evidence="30"Peroxidase TXNRD1 ecNumber evidence="6"1.11.1.2 alternativeName: Thioredoxin reductase TR1 |
| geneName | TXNRD1 GRIM12 KDRF |
| identifier | Q16881 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disulfide bond Electron transport FAD Flavoprotein NADP Nucleus Oxidoreductase Phosphoprotein Proteomics identification Redox-active center Reference proteome Selenocysteine Transport Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | TXNRD1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5649891] ENSEMBL:ENSG00000198431 TXNRD1 [Homo sapiens] |
| secondaryIdentifier | TRXR1_HUMAN B7Z1F4 B7Z3Y8 B7Z904 E9PMY9 F5H780 Q6FI31 Q6VB40 Q6VB41 Q6VB42 Q6VBP2 Q6VBP3 Q6VBP4 Q6VBP5 Q6VBP9 Q6VBQ0 Q6YNQ1 Q76P53 Q7LA96 Q8WVC8 Q99475 Q9UES8 Q9UH79 |
| sequenceLength | 649 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q16881-5 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q16881-5 TXNRD1 (252810)
