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Details on Person UniProt:Q9NQ86 TRIM36
| Class:Id | ReferenceGeneProduct:252553 |
|---|---|
| _chainChangeLog | chain:1-728 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NQ86 TRIM36 |
| _timestamp | 2024-11-03 20:08:12 |
| chain | chain:1-728 |
| checksum | 1D1B4F98325BD73C |
| comment | FUNCTION E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fertilization.CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.SUBUNIT Interacts with CENPH.INTERACTION Found in the acrosomal region of elongated spermatids and mature sperm.ALTERNATIVE PRODUCTS Highly expressed in testis, prostate and brain (PubMed:15145053). Weakly expressed in kidney, lung and heart (PubMed:15145053). Expressed in fetal tissues (PubMed:28087737).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TRIM/RBCC family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: E3 ubiquitin-protein ligase TRIM36 ecNumber evidence="1"2.3.2.27 alternativeName: RING finger protein 98 alternativeName: fullName evidence="16"RING-type E3 ubiquitin transferase TRIM36 alternativeName: Tripartite motif-containing protein 36 alternativeName: Zinc-binding protein Rbcc728 |
| geneName | TRIM36 RBCC728 RNF98 |
| identifier | Q9NQ86 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Coiled coil Cytoplasm Cytoplasmic vesicle Cytoskeleton Disease variant Metal-binding Proteomics identification Reference proteome Repeat Transferase Ubl conjugation pathway Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TRIM36 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999827] ENSEMBL:ENSG00000152503 TRIM36 [Homo sapiens] |
| secondaryIdentifier | TRI36_HUMAN A1L3Z1 A6NDD0 B7Z3V4 B7ZAV7 E9PFI8 Q0P5Z9 |
| sequenceLength | 728 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8973105] UniProt:Q9NQ86-1 TRIM36 [Homo sapiens] [ReferenceIsoform:8973106] UniProt:Q9NQ86-2 TRIM36 [Homo sapiens] [ReferenceIsoform:8973107] UniProt:Q9NQ86-3 TRIM36 [Homo sapiens] [ReferenceIsoform:8973108] UniProt:Q9NQ86-4 TRIM36 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:976029] TRIM36 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NQ86 TRIM36 (252553)
