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Details on Person UniProt:Q17RH7 TPRXL
| Class:Id | ReferenceGeneProduct:252426 |
|---|---|
| _chainChangeLog | chain:1-258 added on Fri February 6 2015;chain:1-258 for 252426 removed on Fri May 5 2023;chain:1-139 for 252426 added on Fri May 5 2023 |
| _displayName | UniProt:Q17RH7 TPRXL |
| _timestamp | 2026-02-20 22:28:00 |
| chain | chain:1-139 |
| checksum | BE1B44D2E7B57051 |
| comment | FUNCTION Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:36074823). Protein produced from maternal transcripts that binds and activates expression of key ZGA marker genes, such as NANOGNB, ZSCAN4, DUXB, KLF5 and DPPA3 (PubMed:36074823). Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif (By similarity).SUBCELLULAR LOCATION Maternally expressed in oocytes (PubMed:36074823). Transcripts start to be translated upon oocyte meiotic resumption and decline after major zygotic genome activation (ZGA) (at protein level) (PubMed:36074823).SIMILARITY Belongs to the paired homeobox family.SEQUENCE CAUTION Wrong choice of frame.ONLINE INFORMATION In the beginning - Issue 256 of March 2023 |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="6"Tetra-peptide repeat homeobox-like protein |
| geneName | TPRXL |
| identifier | Q17RH7 |
| isSequenceChanged | FALSE |
| keyword | Developmental protein DNA-binding Homeobox Nucleus Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | TPRXL |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TPRXL_HUMAN Q8NAM5 |
| sequenceLength | 139 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9818451] TPRXL [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q17RH7 TPRXL (252426)
