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Details on Person UniProt:Q8N7U7 TPRX1
| Class:Id | ReferenceGeneProduct:252424 |
|---|---|
| _chainChangeLog | chain:1-411 added on Sat February 7 2015 |
| _displayName | UniProt:Q8N7U7 TPRX1 |
| _timestamp | 2024-11-03 20:08:10 |
| chain | chain:1-411 |
| checksum | 22507B5AC5EFD40C |
| comment | FUNCTION Transcription factor expressed after fertilization required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:35314832, PubMed:36074823). Binds and activates expression of key ZGA marker genes, such as NANOGNB, ZSCAN4, DUXB, KLF5 and DPPA3 (PubMed:36074823). Binds to regulatory DNA sequences containing a 5'-TAATCC-3' sequence motif (PubMed:36074823).INTERACTION Specifically expressed during early development: expression starts to increase at the 4-cell (4C) stage and culminates at the 8-cell (8C) stage.SIMILARITY Belongs to the paired homeobox family.ONLINE INFORMATION In the beginning - Issue 256 of March 2023 |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="7"Tetra-peptide repeat homeobox protein 1 |
| geneName | TPRX1 |
| identifier | Q8N7U7 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Developmental protein DNA-binding Homeobox Nucleus Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TPRX1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998655] ENSEMBL:ENSG00000178928 TPRX1 [Homo sapiens] |
| secondaryIdentifier | TPRX1_HUMAN A5D8Y3 B2RPL5 |
| sequenceLength | 411 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:252425] UniProt:Q8N7U7-2 TPRX1 [Homo sapiens] [ReferenceIsoform:411361] UniProt:Q8N7U7-1 TPRX1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9818519] TPRX1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8N7U7 TPRX1 (252424)
