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Details on Person UniProt:Q9HCJ0 TNRC6C
| Class:Id | ReferenceGeneProduct:252240 |
|---|---|
| _chainChangeLog | chain:1-1690 added on Fri February 6 2015;chain:1-1690 for 252240 removed on Mon Feb 26 2024;chain:1-1936 for 252240 added on Mon Feb 26 2024 |
| _displayName | UniProt:Q9HCJ0 TNRC6C |
| _timestamp | 2024-11-03 20:12:28 |
| chain | chain:1-1936 |
| checksum | 3392333B087ACE5D |
| comment | FUNCTION Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.SUBUNIT Interacts with one or more of the argonaute family proteins AGO1, AGO2, AGO3 and AGO4. Interacts with PABPC1 and EIF4G1. Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex. Interacts with PAN3; the interaction mediates the association with the PAN complex.INTERACTION The silencing domain, also known as C-terminal effector domain (CED), can act in autonomous repression, including both translational inhibition and mRNA degradation.SIMILARITY Belongs to the GW182 family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Trinucleotide repeat-containing gene 6C protein |
| geneName | TNRC6C KIAA1582 |
| identifier | Q9HCJ0 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative initiation Alternative splicing Coiled coil Methylation Phosphoprotein Proteomics identification Reference proteome RNA-binding RNA-mediated gene silencing Translation regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TNRC6C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003293] ENSEMBL:ENSG00000078687 TNRC6C [Homo sapiens] |
| secondaryIdentifier | TNR6C_HUMAN A0A8Q3SIH5 A0A8Q3SIS0 G3XAB8 Q86UE5 Q8N3D8 Q96MU9 |
| sequenceLength | 1936 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:252241] UniProt:Q9HCJ0-2 TNRC6C [Homo sapiens] [ReferenceIsoform:414432] UniProt:Q9HCJ0-1 TNRC6C [Homo sapiens] [ReferenceIsoform:9862439] Unknown:Q9HCJ0-3 TNRC6C [Homo sapiens] [ReferenceIsoform:9862440] Unknown:Q9HCJ0-4 TNRC6C [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:427776] TNRC6C [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9HCJ0 TNRC6C (252240)
