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Details on Person UniProt:Q96KP6 TNIP3
| Class:Id | ReferenceGeneProduct:252201 |
|---|---|
| _chainChangeLog | chain:1-325 added on Fri February 6 2015 |
| _displayName | UniProt:Q96KP6 TNIP3 |
| _timestamp | 2024-11-03 19:43:55 |
| chain | chain:1-325 |
| checksum | C03EDCCA38B59D29 |
| comment | FUNCTION Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.SUBUNIT Interacts with TNFAIP3. Interacts with polyubiquitin.INTERACTION Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in bone marrow, brain, kidney, spleen, leukocytes and tonsils. Could be detected in heart, salivary gland, adrenal gland, pancreas, ovary and fetal brain. High levels detected in liver, colon, small intestine, muscle, stomach, testis, placenta, thyroid, uterus, prostate, skin and PBL.INDUCTION By Listeria infection. Expression is slightly down-regulated by dexamethasone and slightly up-regulated by IL-10. Strongly induced mRNA and protein expression by lipopolysaccharide.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: TNFAIP3-interacting protein 3 alternativeName: A20-binding inhibitor of NF-kappa-B activation 3 shortName: ABIN-3 alternativeName: Listeria-induced gene protein |
| geneName | TNIP3 ABIN3 LIND |
| identifier | Q96KP6 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Coiled coil Inflammatory response Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TNIP3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000380] ENSEMBL:ENSG00000050730 TNIP3 [Homo sapiens] |
| secondaryIdentifier | TNIP3_HUMAN A1A574 A8K2Z4 B4DVF5 B4E023 Q96PQ3 Q9H780 |
| sequenceLength | 325 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8971699] UniProt:Q96KP6-1 TNIP3 [Homo sapiens] [ReferenceIsoform:8971700] UniProt:Q96KP6-2 TNIP3 [Homo sapiens] [ReferenceIsoform:8971701] UniProt:Q96KP6-3 TNIP3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:561192] TNIP3 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96KP6 TNIP3 (252201)
