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Details on Person UniProt:Q9CQW0 Emc6
| Class:Id | ReferenceGeneProduct:252117 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-110 added on Fri February 6 2015;initiator methionine:1 for 252117 removed on Fri Nov 03 2023;initiator methionine: for 252117 added on Fri Nov 03 2023;initiator methionine: for 252117 removed on Fri Aug 15 2025;initiator methionine:1 for 252117 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9CQW0 Emc6 |
| _timestamp | 2025-08-15 22:00:14 |
| chain | initiator methionine:1 chain:2-110 |
| checksum | 5120B6E4CC12FD48 |
| comment | FUNCTION Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes.SUBUNIT Component of the ER membrane protein complex (EMC).SUBCELLULAR LOCATION Belongs to the EMC6 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: ER membrane protein complex subunit 6 alternativeName: Transmembrane protein 93 |
| geneName | Emc6 Tmem93 |
| identifier | Q9CQW0 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Endoplasmic reticulum Membrane Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2455454] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Emc6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | EMC6_MOUSE Q9CQ41 |
| sequenceLength | 110 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9986528] Emc6 [endoplasmic reticulum membrane] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9CQW0 Emc6 (252117)
