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Details on Person UniProt:Q5J8M3 EMC4
| Class:Id | ReferenceGeneProduct:252104 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-183 added on Fri February 6 2015;initiator methionine:1 for 252104 removed on Fri Nov 03 2023;initiator methionine: for 252104 added on Fri Nov 03 2023;initiator methionine: for 252104 removed on Fri Aug 15 2025;initiator methionine:1 for 252104 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q5J8M3 EMC4 |
| _timestamp | 2025-08-15 21:29:48 |
| chain | initiator methionine:1 chain:2-183 |
| checksum | 96888D46FF22DEDE |
| comment | FUNCTION Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).SUBUNIT Component of the ER membrane protein complex (EMC).INTERACTION Could also be a single-pass transmembrane protein with cytosolic N-terminus and lumenal C-terminus.ALTERNATIVE PRODUCTS Isoform 1 is expressed in brain and heart. Isoform 2 is expressed in heart.SIMILARITY Belongs to the EMC4 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: ER membrane protein complex subunit 4 alternativeName: Cell proliferation-inducing gene 17 protein alternativeName: Transmembrane protein 85 |
| geneName | EMC4 TMEM85 HSPC184 PIG17 |
| identifier | Q5J8M3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Apoptosis Endoplasmic reticulum Membrane Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | EMC4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001739] ENSEMBL:ENSG00000128463 EMC4 [Homo sapiens] |
| secondaryIdentifier | EMC4_HUMAN A8K3A9 B4DJQ4 Q96KX9 Q9BUI5 Q9P0T9 |
| sequenceLength | 183 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:252105] UniProt:Q5J8M3-2 EMC4 [Homo sapiens] [ReferenceIsoform:407148] UniProt:Q5J8M3-1 EMC4 [Homo sapiens] [ReferenceIsoform:424599] UniProt:Q5J8M3-3 EMC4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9947665] EMC4 [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q5J8M3 EMC4 (252104)
