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Details on Person UniProt:P24033 cdk1-b

Class:Id	ReferenceGeneProduct:2520861
_chainChangeLog	chain:1-302 added on Fri February 6 2015
_displayName	UniProt:P24033 cdk1-b
_timestamp	2025-02-21 19:05:16
chain	chain:1-302
checksum	FA9DC156392D7CBC
comment	FUNCTION Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (By similarity). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (By similarity). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (By similarity).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY [DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)ACTIVITY REGULATION Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it.SUBUNIT Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with spdya.SUBCELLULAR LOCATION Phosphorylation at Tyr-15 by wee1 and wee2 inhibits the protein kinase activity and acts negative regulator of entry into mitosis (G2 to M transition).SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
created	[InstanceEdit:2520858] Orlic-Milacic, M, 2012-10-11
description	recommendedName: Cyclin-dependent kinase 1-B shortName: CDK1-B ecNumber evidence="2"2.7.11.22 ecNumber evidence="3"2.7.11.23 alternativeName: Cell division control protein 2 homolog 2 alternativeName: Cell division control protein 2-B alternativeName: Cell division protein kinase 1 alternativeName: p34 protein kinase 2
geneName	cdk1-b cdc2 cdc2x1.2
identifier	P24033
isSequenceChanged	FALSE
keyword	ATP-binding Cell cycle Cell division Kinase Mitosis Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase
modified	[InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	cdk1-b
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	CDK1B_XENLA Q7SZ44
sequenceLength	302
species	[Species:51320] Xenopus laevis
(referenceEntity)	[EntityWithAccessionedSequence:2520864] p-T161-Cdk1-B [cytosol] [Xenopus laevis]
(referenceSequence)	[ModifiedResidue:2520860] O-phospho-L-threonine at 161
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No pathways have been reviewed or authored by UniProt:P24033 cdk1-b (2520861)