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Details on Person UniProt:Q8K273 Mmgt1
| Class:Id | ReferenceGeneProduct:251995 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Sat February 7 2015;chain:21-131 added on Sat February 7 2015;signal peptide:1-20 removed on Fri May 6 2016;chain:21-131 removed on Fri May 6 2016;chain:1-131 added on Fri May 6 2016 |
| _displayName | UniProt:Q8K273 Mmgt1 |
| _timestamp | 2023-11-03 15:01:53 |
| chain | chain:1-131 |
| checksum | DB3841F8CCBD801E |
| comment | FUNCTION Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). May be involved Mg(2+) transport (PubMed:18057121).SUBUNIT Component of the ER membrane protein complex (EMC).SUBCELLULAR LOCATION Abundant in heart muscle and kidney with lower levels in liver and brain and very little expression in intestine or colon. In kidney, highest levels in distal convoluted tubule.INDUCTION Up-regulated by low extracellular Mg(2+).SIMILARITY Belongs to the membrane magnesium transporter (TC 1.A.67) family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="1"ER membrane protein complex subunit 5 alternativeName: fullName evidence="3"Membrane magnesium transporter 1 alternativeName: fullName evidence="6"Transmembrane protein 32 |
| geneName | Mmgt1 Emc5 Tmem32 |
| identifier | Q8K273 |
| isSequenceChanged | FALSE |
| keyword | Endoplasmic reticulum Endosome Golgi apparatus Magnesium Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2455454] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8869714] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Mmgt1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | EMC5_MOUSE A7UH87 |
| sequenceLength | 131 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:5336458] Mmgt1 [Golgi membrane] [Mus musculus] [EntityWithAccessionedSequence:9986531] Mmgt1 [endoplasmic reticulum membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q8K273 Mmgt1 (251995)
