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Details on Person UniProt:Q8NEW7 TMIE
| Class:Id | ReferenceGeneProduct:251951 |
|---|---|
| _chainChangeLog | signal peptide:1-27 added on Sat February 7 2015;chain:28-156 added on Sat February 7 2015 |
| _displayName | UniProt:Q8NEW7 TMIE |
| _timestamp | 2026-02-20 21:55:13 |
| chain | signal peptide:1-27 chain:28-156 |
| checksum | 457DC5D0C5F66F03 |
| comment | FUNCTION Auxiliary subunit of the mechanotransducer (MET) non-specific cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. May contribute to the formation of the pore.SUBUNIT Forms the MET channel composed of TMC (TMC1 or TMC2), TMIE, TOMT, CIB (CIB2 or CIB3), LHPL5 and PCDH15.SUBCELLULAR LOCATION Expressed in many tissues.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Transmembrane inner ear expressed protein |
| geneName | TMIE |
| identifier | Q8NEW7 |
| isSequenceChanged | FALSE |
| keyword | Deafness Disease variant Membrane Non-syndromic deafness Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | TMIE |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001504] ENSEMBL:ENSG00000181585 TMIE [Homo sapiens] |
| secondaryIdentifier | TMIE_HUMAN A0AV93 A8K0R0 |
| sequenceLength | 156 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:9658863] TMIE [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8NEW7 TMIE (251951)
