Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q8TDI7-3 TMC2
| Class:Id | ReferenceIsoform:251845 |
|---|---|
| _chainChangeLog | chain:1-906 added on Sat February 7 2015 |
| _displayName | UniProt:Q8TDI7-3 TMC2 |
| _timestamp | 2024-11-03 20:12:26 |
| chain | chain:1-906 |
| checksum | 0EB7A3E35C870E2A |
| comment | FUNCTION Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (PubMed:11850618). The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located (By similarity). TMC2 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cell transduction current of the mammalian inner ear (By similarity).CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)SUBUNIT Forms the MET channel composed of TMC dimer (TMC1 or TMC2), TMIE, TOMT, CIB (CIB2 or CIB3), LHFPL5 and PDH15. The interaction of TMC1 and TMC2 with TOMT is required for the transportation of TMC1/2 into the stereocilia of hair cells. Interacts (via N-terminus) with both isoforms CD1 and CD3 of PCDH15. Can form a heterodimer with TMC1, TMC5 or TMC7.SUBCELLULAR LOCATION Localized to the stereocilia tips of the cochlear hair cells and plasma membranes of cuticular plates.ALTERNATIVE PRODUCTS Detected in fetal cochlea.SIMILARITY Belongs to the TMC family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Transmembrane channel-like protein 2 alternativeName: Transmembrane cochlear-expressed protein 2 |
| geneName | TMC2 C20orf145 UNQ907/PRO1928 |
| identifier | Q8TDI7 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Ion channel Ion transport Membrane Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TMC2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002695] ENSEMBL:ENSG00000149488 TMC2 [Homo sapiens] |
| secondaryIdentifier | TMC2_HUMAN Q5JXT0 Q5JXT1 Q6UWW4 Q6ZS41 Q8N9F3 Q9BYN2 Q9BYN3 Q9BYN4 Q9BYN5 |
| sequenceLength | 906 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q8TDI7-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8TDI7-3 TMC2 (251845)
