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Details on Person serine palmitoyltransferase complex

Class:Id	GO_CellularComponent:25161
_displayName	serine palmitoyltransferase complex
_timestamp	2024-08-09 20:40:11
accession	0017059
definition	A protein complex that catalyses the condensation of L-serine with palmitoyl-CoA to form 3-ketosphinganine, the sphingoid base which is the starting point for all sphingolipids. In bacteria the enzyme is a cytoplasmic homodimer, whereas in eukaryotes the enzyme is a multiprotein complex localised to the endoplasmic reticulum. The eukaryotic complex consists of catalytic components (SPTLC1, SPTLC2 and SPTLC3 in humans; LCB1 and LCB2 in S. cerevisiae) and regulatory components, which include activators (SPTSSA/SPTSSB in humans, TSC3 in S. cerevisiae) and negative regulators (ORMDL1/ORMDL2/ORMDL3 in humans, ORM1/2 in S. cerevisiae ).
instanceOf	[GO_CellularComponent:1221014] palmitoyltransferase complex [GO_CellularComponent:5263525] transferase complex [GO_CellularComponent:5263325] catalytic complex [GO_CellularComponent:258170] protein-containing complex [GO_CellularComponent:357] cellular_component
modified	[InstanceEdit:160533] Schmidt, EE, 2005-03-23 05:24:35 [InstanceEdit:162607] Schmidt, EE, 2005-04-01 11:06:09 [InstanceEdit:171322] Schmidt, EE, 2006-02-06 10:50:16 [InstanceEdit:258122] Kanapin, EE, 2008-03-27 12:15:20 [InstanceEdit:357819] Kanapin, EE, 2008-06-18 10:45:39 [InstanceEdit:376438] Kanapin, EE, 2008-09-08 10:23:04 [InstanceEdit:383393] Kanapin, AA, 2008-11-26 13:49:44 [InstanceEdit:396309] Kanapin, EE, 2009-03-09 13:26:57 [InstanceEdit:422569] Kanapin, EE [InstanceEdit:436347] Kanapin, EE [InstanceEdit:447572] Kanapin, EE [InstanceEdit:526073] Kanapin, AA [InstanceEdit:528085] Kanapin, AA [InstanceEdit:615500] Kanapin, AA [InstanceEdit:797782] Kanapin, AA [InstanceEdit:937668] Yung, CK [InstanceEdit:1042299] Yung, CK [InstanceEdit:1220942] Yung, CK [InstanceEdit:1301023] Yung, CK [InstanceEdit:1552540] Yung, CK [InstanceEdit:1996004] Yung, CK [InstanceEdit:2132408] Weiser, JD [InstanceEdit:2133145] Weiser, JD [InstanceEdit:2266118] Weiser, JD [InstanceEdit:2266147] Weiser, JD [InstanceEdit:2454362] Weiser, JD [InstanceEdit:2455542] Weiser, JD [InstanceEdit:2587907] Weiser, JD [InstanceEdit:3132285] Weiser, JD [InstanceEdit:3445953] Weiser, JD [InstanceEdit:4341211] Weiser, JD [InstanceEdit:5083267] Weiser, JD [InstanceEdit:5263134] Weiser, JD [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689214] Cook, Justin, 2020-05-15 [InstanceEdit:9715950] Shorser, Solomon, 2021-02-17 [InstanceEdit:9730069] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750511] Weiser, JD, 2021-08-11 [InstanceEdit:9758049] Weiser, JD, 2021-11-08 [InstanceEdit:9767446] Wright, Adam, 2022-02-25 [InstanceEdit:9773560] Weiser, Joel, 2022-05-04 [InstanceEdit:9910546] Weiser, Joel, 2024-05-14 [InstanceEdit:9917727] Weiser, Joel, 2024-08-09 [InstanceEdit:9917761] Weiser, Joel, 2024-08-09 [InstanceEdit:9926777] Weiser, Joel, 2024-11-03 [InstanceEdit:9939260] Weiser, Joel, 2025-02-21 [InstanceEdit:9948590] Weiser, Joel, 2025-05-21 [InstanceEdit:9963890] Weiser, Joel, 2025-08-15 [InstanceEdit:9970828] Weiser, Joel, 2025-10-31 [InstanceEdit:9983368] Weiser, Joel, 2026-02-22 [InstanceEdit:9989188] Weiser, Joel, 2026-05-15
name	serine palmitoyltransferase complex
referenceDatabase	[ReferenceDatabase:1] GO
(goCellularComponent)	[Complex:428140] PXLP-K-SPTLC1:PXLP-K379-SPTLC2:SPTSS [endoplasmic reticulum membrane] [Homo sapiens] [Complex:428177] PXLP-K-SPTLC1:PXLP-K371-SPTLC3:SPTSS [endoplasmic reticulum membrane] [Homo sapiens] [Complex:433536] SPTLC1:SPTLC2 [endoplasmic reticulum membrane] [Gallus gallus] [Complex:433609] SPTLC1:SPTLC3 [endoplasmic reticulum membrane] [Gallus gallus]
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No pathways have been reviewed or authored by serine palmitoyltransferase complex (25161)