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Details on Person cGMP:CNG transports Na+ and Ca2+ into the rod outer segment

Class:Id	Reaction:2514867
_displayName	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment
_doRelease	TRUE
_timestamp	2013-05-31 09:37:50
authored	[InstanceEdit:2514885] Jassal, B, 2012-10-11
catalystActivity	[CatalystActivity:2514862] intracellularly cyclic nucleotide-activated monoatomic cation channel activity of cGMP:CNG channel [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2514885] Jassal, B, 2012-10-11
edited	[InstanceEdit:2514885] Jassal, B, 2012-10-11
input	[SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:74310] Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression. [LiteratureReference:3223235] A new subunit of the cyclic nucleotide-gated cation channel in retinal rods [LiteratureReference:2534413] The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry [LiteratureReference:3262480] Electrical properties of the light-sensitive conductance of rods of the salamander Ambystoma tigrinum [LiteratureReference:3262456] CNG and HCN channels: two peas, one pod [LiteratureReference:3262469] Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment [LiteratureReference:3262451] Calcium and magnesium fluxes across the plasma membrane of the toad rod outer segment [LiteratureReference:74006] Subunit stoichiometry of the CNG channel of rod photoreceptors. [LiteratureReference:74007] Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit.
modified	[InstanceEdit:2534412] Jassal, Bijay, 2012-10-26 [InstanceEdit:3223221] Jassal, Bijay, 2013-03-25 [InstanceEdit:3262437] Jassal, Bijay, 2013-04-10 [InstanceEdit:3270611] Jassal, Bijay, 2013-04-11 [InstanceEdit:3632877] Jassal, Bijay, 2013-05-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	cGMP:CNG transports Na+ and Ca2+ into the rod outer segment
output	[SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:83910] Na+ [cytosol]
releaseDate	2013-06-11
reviewed	[InstanceEdit:3270610] Makino, C, 2013-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3654226] R-HSA-2514867.2
summation	[Summation:2514889] The cGMP-gated (CNG) channels are heterotetramers of three a...
(hasEvent)	[Pathway:2485179] Activation of the phototransduction cascade [Homo sapiens]
(precedingEvent)	[Reaction:2514891] SLC24A1 exchanges 4Na+ for Ca2+, K+ [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786712] Update Tracker - [Reaction:2514867] cGMP:CNG transports Na+ and Ca2+ into the rod outer segment - v48:[removeRegulator]
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