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Details on Person Fibrillin-1 degradation by MMP3, CTSK, CTSL2

Class:IdReaction:2514772
_displayNameFibrillin-1 degradation by MMP3, CTSK, CTSL2
_doReleaseTRUE
_timestamp2013-09-05 11:51:56
authored[InstanceEdit:2426629] Jupe, S, 2012-08-08
catalystActivity[CatalystActivity:1604695] serine-type endopeptidase activity of MMP3, CTSK, CTSL2 [extracellular region]
compartment[Compartment:984] extracellular region
created[InstanceEdit:2514810] Jupe, S, 2012-10-10
edited[InstanceEdit:4090280] Jupe, S, 2013-08-13
input[Polymer:2159874] Fibrillin-1 [extracellular region] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2485133] Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling
[LiteratureReference:2514804] Classical and neonatal Marfan syndrome mutations in fibrillin-1 cause differential protease susceptibilities and protein function
modified[InstanceEdit:2514825] Jupe, S, 2012-10-10
[InstanceEdit:3791165] Jupe, S, 2013-07-05
[InstanceEdit:4093350] Jupe, S, 2013-08-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameFibrillin-1 degradation by MMP3, CTSK, CTSL2
output[Polymer:2514812] Cleaved fibrillin-1 [extracellular region] [Homo sapiens]
releaseDate2013-09-18
reviewed[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013-08-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:4545307] R-HSA-2514772.2
summation[Summation:2514780] Fibrillin-1 can be degraded by MMP3 (Ashworth et al. 1999) a...
(hasEvent)[Pathway:1474228] Degradation of the extracellular matrix [Homo sapiens]
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