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Details on Person ITPA hydrolyses XTP to XMP

Class:IdReaction:2509831
_displayNameITPA hydrolyses XTP to XMP
_doReleaseTRUE
_timestamp2021-07-20 19:41:55
authored[InstanceEdit:2509814] D'Eustachio, P, 2012-10-05
catalystActivity[CatalystActivity:2509849] XTP diphosphatase activity of ITPA dimer [cytosol]
catalystActivityReference[CatalystActivityReference:9643618] XTP diphosphatase activity of ITPA dimer [cytosol] Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene
compartment[Compartment:70101] cytosol
created[InstanceEdit:2509826] D'Eustachio, P, 2012-10-05
edited[InstanceEdit:2509814] D'Eustachio, P, 2012-10-05
input[SimpleEntity:2509848] XTP [cytosol]
[SimpleEntity:29356] H2O [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:2509834] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals
[LiteratureReference:2509828] Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene
modified[InstanceEdit:2581439] D'Eustachio, P, 2012-11-13
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9737588] D'Eustachio, Peter, 2021-07-20
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameITPA hydrolyses XTP to XMP
XTP + H2O => XMP + PPi
output[SimpleEntity:111584] XMP [cytosol]
[SimpleEntity:111294] PPi [cytosol]
[SimpleEntity:70106] H+ [cytosol]
regulatedBy[Requirement:2509854] Requirement by 'Mg2+ [cytosol]'
regulationReference[RegulationReference:9642836] Requirement by 'Mg2+ [cytosol]' Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene
releaseDate2012-12-04
reviewed[InstanceEdit:2509804] Ito, Riyoko, 2012-10-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3200586] R-HSA-2509831.6
summation[Summation:2509832] Cytosolic ITPA dimer catalyzes the reaction of XTP and water...
(hasEvent)[Pathway:74259] Purine catabolism [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775552] Update Tracker - [Reaction:2509831] ITPA hydrolyses XTP to XMP - v78:[addOutput]
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