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Details on Person NUDT16 hydrolyses dIDP to dIMP

Class:IdReaction:2509793
_displayNameNUDT16 hydrolyses dIDP to dIMP
_doReleaseTRUE
_timestamp2025-12-10 22:49:56
authored[InstanceEdit:2509814] D'Eustachio, P, 2012-10-05
catalystActivity[CatalystActivity:2509802] dIDP phosphatase activity of NUDT16 dimer [nucleoplasm]
catalystActivityReference[CatalystActivityReference:9643454] dIDP diphosphatase activity of NUDT16 dimer [nucleoplasm] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:2509808] D'Eustachio, P, 2012-10-05
crossReference[DatabaseIdentifier:9976357] RHEA:35212
edited[InstanceEdit:2509814] D'Eustachio, P, 2012-10-05
input[SimpleEntity:2509796] dIDP [nucleoplasm]
[SimpleEntity:113518] H2O [nucleoplasm]
isChimericFALSE
literatureReference[LiteratureReference:2509797] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest
[LiteratureReference:2509799] Metal determines efficiency and substrate specificity of the nuclear NUDIX decapping proteins X29 and H29K (Nudt16)
modified[InstanceEdit:2509820] D'Eustachio, P, 2012-10-05
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9737588] D'Eustachio, Peter, 2021-07-20
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
nameNUDT16 hydrolyses dIDP to dIMP
dIDP + H2O => dIMP + phosphate + H(+)
output[SimpleEntity:2509805] dIMP [nucleoplasm]
[SimpleEntity:113550] Pi [nucleoplasm]
[SimpleEntity:9668967] H+ [nucleoplasm]
regulatedBy[Requirement:2509821] Requirement by 'Mg2+ [nucleoplasm]'
regulationReference[RegulationReference:9642455] Requirement by 'Mg2+ [nucleoplasm]' NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest
releaseDate2012-12-04
reviewed[InstanceEdit:2509804] Ito, Riyoko, 2012-10-05
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:3200199] R-HSA-2509793.7
summation[Summation:2509817] NUDT16 dimer catalyzes the reaction of dIDP and water to for...
(hasEvent)[Pathway:2393930] Phosphate bond hydrolysis by NUDT proteins [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775514] Update Tracker - [Reaction:2509793] NUDT16 hydrolyses dIDP to dIMP - v78:[addOutput]
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