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Details on Person UniProt:Q8IZJ6 TDH

Class:Id	ReferenceGeneProduct:250833
_chainChangeLog	transit peptide:1- added on Fri February 6 2015;chain:-230 added on Fri February 6 2015
_displayName	UniProt:Q8IZJ6 TDH
_timestamp	2023-11-03 17:35:08
chain	transit peptide:1- chain:-230
checksum	4163D462B322EF98
comment	SUBCELLULAR LOCATION Expressed in all tissues examined. Detected in most cell types examined, but not observed in endothelial cells, glioma cell lines and some leukemia cell lines.SIMILARITY Belongs to the NAD(P)-dependent epimerase/dehydratase family.CAUTION According to PubMed:12361482, the human TDH gene is an expressed pseudogene encoding non-functional truncated proteins that are unable to make appropriate contacts with the substrates, L-threonine and NAD(+). Although all exons expected to encode a functional L-threonine 3-dehydrogenase of 369 residues are present in the human genome, all transcripts described encode truncated proteins that result from mutations within the gene causing the loss of acceptor splice site preceding exon 4 and exon 6.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: Inactive L-threonine 3-dehydrogenase, mitochondrial alternativeName: Short chain dehydrogenase/reductase family 14E member 1 pseudogene
geneName	TDH SDR14E1P
identifier	Q8IZJ6
isSequenceChanged	FALSE
keyword	Alternative splicing Mitochondrion Reference proteome Transit peptide
modified	[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
name	TDH
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	TDH_HUMAN Q8IZJ5 Q96LV6
sequenceLength	230
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:250834] UniProt:Q8IZJ6-2 TDH [Homo sapiens] [ReferenceIsoform:250835] UniProt:Q8IZJ6-3 TDH [Homo sapiens] [ReferenceIsoform:410973] UniProt:Q8IZJ6-1 TDH [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:6798657] TDH [mitochondrial inner membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q8IZJ6 TDH (250833)