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Details on Person UniProt:Q8WW35 DYNLT2B
| Class:Id | ReferenceGeneProduct:250746 |
|---|---|
| _chainChangeLog | chain:1-142 added on Fri February 6 2015 |
| _displayName | UniProt:Q8WW35 DYNLT2B |
| _timestamp | 2024-11-03 20:00:39 |
| chain | chain:1-142 |
| checksum | 9497791BE19EFFCB |
| comment | FUNCTION Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. Required for proper retrograde ciliary transport.SUBUNIT Light chain of the cytoplasmic dynein complex 2, a multisubunit complex composed at least of eleven different proteins (PubMed:25205765, PubMed:26044572). The cytoplasmic dynein 2 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs). Among them, a heavy chain (DYNC2H1), two intermediate chains (DYNC2I2 and DYNC2I1), a light intermediate chain (DYNC2LI1), and a light chain (DYNLT2B) are unique to the dynein-2 complex, but a subset of the light chains are also shared by dynein-1 and dynein-2 complexes (PubMed:25205765, PubMed:26044572). Interacts with DYNC2I1 (PubMed:26044572). The dimer DYNLT2B-DYNLT1/DYNLT3 interacts with DYNC2I1; this interaction is crucial for retrograde trafficking of ciliary proteins (PubMed:26044572, PubMed:29742051).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the dynein light chain Tctex-type family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="5"Dynein light chain Tctex-type protein 2B alternativeName: Tctex1 domain-containing protein 2 |
| geneName | DYNLT2B TCTEX1D2 |
| identifier | Q8WW35 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Ciliopathy Cytoplasm Disease variant Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | DYNLT2B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988150] ENSEMBL:ENSG00000213123 DYNLT2B [Homo sapiens] |
| secondaryIdentifier | DYT2B_HUMAN A6NCN5 |
| sequenceLength | 142 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5624891] DYNLT2B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5624893] DYNLT2B [cilium] [Homo sapiens] [EntityWithAccessionedSequence:5625403] DYNLT2B [ciliary tip] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8WW35 DYNLT2B (250746)
