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Details on Person UniProt:Q9BTW9 TBCD
| Class:Id | ReferenceGeneProduct:250681 |
|---|---|
| _chainChangeLog | chain:1-1192 added on Fri February 6 2015 |
| _displayName | UniProt:Q9BTW9 TBCD |
| _timestamp | 2024-11-03 19:48:55 |
| chain | chain:1-1192 |
| checksum | C46BE2048A5FEBC2 |
| comment | FUNCTION Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374).SUBUNIT Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with PPP2CB (By similarity). Part of a supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state (PubMed:10831612). Interacts with ARL2; interaction is enhanced with the GDP-bound form of ARL2 (PubMed:10831612, PubMed:27666374). Does not interact with ARL3, ARL4A and ARL4D (PubMed:10831612). Interacts with beta tubulin (PubMed:10831612, PubMed:27666370, PubMed:27666374). Interacts with TBCE (PubMed:27666374).INTERACTION Localized in cell-cell contacts.ALTERNATIVE PRODUCTS Ubiquitously expressed.INDUCTION Down-regulated by shear stress.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TBCD family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Tubulin-specific chaperone D alternativeName: Beta-tubulin cofactor D shortName: tfcD alternativeName: SSD-1 alternativeName: Tubulin-folding cofactor D |
| geneName | TBCD KIAA0988 SSD1 TFCD PP1096 |
| identifier | Q9BTW9 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell junction Cell membrane Chaperone Cytoplasm Cytoskeleton Disease variant GTPase activation Membrane Neurodegeneration Proteomics identification Reference proteome Repeat Tight junction |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TBCD |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996311] ENSEMBL:ENSG00000141556 TBCD [Homo sapiens] |
| secondaryIdentifier | TBCD_HUMAN O95458 Q7L8K1 Q8IXP6 Q8NAX0 Q8WYH4 Q96E74 Q9UF82 Q9UG46 Q9Y2J3 |
| sequenceLength | 1192 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:250682] UniProt:Q9BTW9-2 TBCD [Homo sapiens] [ReferenceIsoform:250683] UniProt:Q9BTW9-3 TBCD [Homo sapiens] [ReferenceIsoform:250684] UniProt:Q9BTW9-4 TBCD [Homo sapiens] [ReferenceIsoform:250685] UniProt:Q9BTW9-5 TBCD [Homo sapiens] [ReferenceIsoform:413406] UniProt:Q9BTW9-1 TBCD [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:379540] TBCD [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BTW9 TBCD (250681)
