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Details on Person UniProt:Q3ZCM7 TUBB8
| Class:Id | ReferenceGeneProduct:250626 |
|---|---|
| _chainChangeLog | chain:1-444 added on Fri February 6 2015 |
| _displayName | UniProt:Q3ZCM7 TUBB8 |
| _timestamp | 2024-11-03 20:16:59 |
| chain | chain:1-444 |
| checksum | 3EC4AC10946BF590 |
| comment | FUNCTION Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871, PubMed:34509376).COFACTOR Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.INTERACTION Expressed at a high level in oocytes, at different stages of development.DOMAIN The MREI motif is common among all beta-tubulin isoforms and may be critical for tubulin autoregulation.PTM Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Glutamylation is also involved in cilia motility (By similarity).PTM Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into cilia and flagella axonemes, which is required for their stability and maintenance. Flagella glycylation controls sperm motility. Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally.PTM Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the tubulin family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="13"Tubulin beta-8 chain alternativeName: fullName evidence="15"Tubulin beta 8 class VIII |
| geneName | TUBB8 |
| identifier | Q3ZCM7 |
| isSequenceChanged | FALSE |
| keyword | Cytoplasm Cytoskeleton Disease variant GTP-binding Isopeptide bond Magnesium Metal-binding Microtubule Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TUBB8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000363] ENSEMBL:ENSG00000261456 TUBB8 [Homo sapiens] |
| secondaryIdentifier | TBB8_HUMAN Q5SQX9 Q8WZ78 |
| sequenceLength | 444 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6805243] TUBB8 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8867387] Polyglutamyl-TUBB8 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8867423] Polyglycyl-TUBB8 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9648031] TUBB8 [spindle] [Homo sapiens] [EntityWithAccessionedSequence:9962332] TUBB8 [cilium] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8867432] L-isoglutamyl-polyglutamic acid at unknown position [ModifiedResidue:8867442] L-isoglutamyl-polyglycine at unknown position |
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No pathways have been reviewed or authored by UniProt:Q3ZCM7 TUBB8 (250626)
