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Details on Person UniProt:Q96GW9 MARS2
| Class:Id | ReferenceGeneProduct:250077 |
|---|---|
| _chainChangeLog | transit peptide:1-29 added on Fri February 6 2015;chain:30-593 added on Fri February 6 2015 |
| _displayName | UniProt:Q96GW9 MARS2 |
| _timestamp | 2025-02-21 19:43:49 |
| chain | transit peptide:1-29 chain:30-593 |
| checksum | A5076FD9F31F4B96 |
| comment | CATALYTIC ACTIVITY tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphateBIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 7.8-8.2.SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Methionine--tRNA ligase, mitochondrial ecNumber: 6.1.1.10 alternativeName: Methionyl-tRNA synthetase 2 alternativeName: Mitochondrial methionyl-tRNA synthetase shortName: MtMetRS |
| geneName | MARS2 |
| identifier | Q96GW9 |
| isSequenceChanged | FALSE |
| keyword | Aminoacyl-tRNA synthetase ATP-binding Deafness Disease variant Ligase Mitochondrion Neurodegeneration Nucleotide-binding Primary mitochondrial disease Protein biosynthesis Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MARS2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002672] ENSEMBL:ENSG00000247626 MARS2 [Homo sapiens] |
| secondaryIdentifier | SYMM_HUMAN A0AVC3 Q76E79 Q8IW62 Q8N7N4 |
| sequenceLength | 593 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:379555] MARS2 [mitochondrial matrix] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96GW9 MARS2 (250077)
