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Details on Person Cohesin complexes dissociate from chromosomal arms in promet...

Class:Id	Summation:2500232
_displayName	Cohesin complexes dissociate from chromosomal arms in promet...
_timestamp	2012-11-01 14:21:37
created	[InstanceEdit:2500237] Orlic-Milacic, M, 2012-10-01
literatureReference	[LiteratureReference:2470265] Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1 [LiteratureReference:2470251] Wapl controls the dynamic association of cohesin with chromatin [LiteratureReference:2470256] Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase [LiteratureReference:2485011] Sororin mediates sister chromatid cohesion by antagonizing Wapl [LiteratureReference:163039] Cohesin cleavage by separase required for anaphase and cytokinesis in human cells [LiteratureReference:163990] Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2 [LiteratureReference:2468289] Interaction of Sororin protein with polo-like kinase 1 mediates resolution of chromosomal arm cohesion [LiteratureReference:2468284] Regulation of sororin by Cdk1-mediated phosphorylation [LiteratureReference:2470942] Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression [LiteratureReference:2500234] Identification of Xenopus SMC protein complexes required for sister chromatid cohesion
modified	[InstanceEdit:2500261] Orlic-Milacic, M, 2012-10-01 [InstanceEdit:2505659] Orlic-Milacic, M, 2012-10-02 [InstanceEdit:2545202] Orlic-Milacic, M, 2012-11-01
text	Cohesin complexes dissociate from chromosomal arms in prometaphase, leading to sister chromatid resolution. Sister chromatid resolution involves separation of sister chromosomal arms while cohesion at sister centromeres persists (Losada et al. 1998, Hauf et al. 2001, Hauf et al. 2005). Cohesin and CDCA5 (Sororin) simultaneously dissociate from chromosomal arms in prometaphase (Nishiyama et al. 2010, Zhang et al. 2011). This process, triggered by CDK1-mediated phosphorylation of CDCA5 (Dreier et al. 2011, Zhang et al. 2011) and PLK1-mediated phosphorylation of the STAG2 cohesin subunit (Hauf et al. 2005), is controlled by WAPAL (Gandhi et al. 2006, Kueng et al. 2006, Shintomi and Hirano 2009). WAPAL controls cohesion of sister chromatids likely through competing with CDCA5 for binding to cohesin-associated PDS5 (PDS5A and PDS5B) (Nishiyama et al. 2010). While the interaction of WAPAL with PDS5 depends on CDCA5 (Nishiyama et al. 2010), WAPAL maintains its association with cohesin through interaction with cohesin subunits (Kueng et al. 2006, Shintomi and Hirano 2009).
(summation)	[Reaction:2467794] Resolution of sister chromatids [Homo sapiens]
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