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Details on Person UniProt:Q9UJZ1 STOML2
| Class:Id | ReferenceGeneProduct:249759 |
|---|---|
| _chainChangeLog | transit peptide:1-28 added on Sat February 7 2015;chain:29-356 added on Sat February 7 2015 |
| _displayName | UniProt:Q9UJZ1 STOML2 |
| _timestamp | 2024-11-03 20:21:39 |
| chain | transit peptide:1-28 chain:29-356 |
| checksum | 672331B57C82654E |
| comment | FUNCTION Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.SUBUNIT Forms homooligomers. Interacts with MFN2; may form heterooligomers. Interacts with CACNA2D2 (By similarity). Interacts with PHB1 and PHB2; recruits them to cardiolipin-enriched mitochondrial membranes and stabilizes them.INTERACTION Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain (PubMed:21746876). Also associates with the actin cytoskeleton and membrane rafts in activated T-cells (PubMed:10713127, PubMed:18641330). A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells (PubMed:22623988).ALTERNATIVE PRODUCTS Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level).INDUCTION Up-regulated in activated B- and T-cells and upon mitochondrial stress by chloramphenicol.PTM Hyperphosphorylated at Ser-17 in some patients with monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia due to impaired dephosphorylation by PP2A.MISCELLANEOUS Paratarg-7/STOML2 is a frequent autoantigenic target in monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia, 3 B-cell neoplasms associated with excessive secretion of a single monoclonal gammaglobulin (also named paraprotein) in the blood.SIMILARITY Belongs to the band 7/mec-2 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Stomatin-like protein 2, mitochondrial shortName: SLP-2 alternativeName: EPB72-like protein 2 alternativeName: Paraprotein target 7 shortName: Paratarg-7 |
| geneName | STOML2 SLP2 HSPC108 |
| identifier | Q9UJZ1 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Cell membrane Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Lipid-binding Lipoprotein Membrane Mitochondrion Mitochondrion inner membrane Phosphoprotein Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | STOML2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000344] ENSEMBL:ENSG00000165283 STOML2 [Homo sapiens] |
| secondaryIdentifier | STML2_HUMAN B4E1K7 D3DRN3 O60376 Q53G29 Q96FY2 Q9P042 |
| sequenceLength | 356 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965857] UniProt:Q9UJZ1-1 STOML2 [Homo sapiens] [ReferenceIsoform:8965858] UniProt:Q9UJZ1-2 STOML2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:8953739] STOML2 [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UJZ1 STOML2 (249759)
