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Details on Person UniProt:Q8IYB3 SRRM1

Class:Id	ReferenceGeneProduct:249492
_chainChangeLog	chain:1-904 added on Fri February 6 2015
_displayName	UniProt:Q8IYB3 SRRM1
_timestamp	2024-11-03 20:16:50
chain	chain:1-904
checksum	27D4D2A48EDBFED3
comment	FUNCTION Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.SUBUNIT Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Component of the minor spliceosome, which splices U12-type introns (PubMed:33509932). Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, PRPF8, NCBP1, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with DDX39B, CPSF1, RBM8A, RNPS1, and ALYREF/THOC4. Seems to be a compound of RNA export complexes that are released from speckles in a ATP-dependent manner.INTERACTION Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown (PubMed:29973724). Phosphorylation by DYRK3 promotes disassembly of nuclear speckles (PubMed:29973724).PTM Citrullinated by PADI4.SIMILARITY Belongs to the splicing factor SR family.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: Serine/arginine repetitive matrix protein 1 alternativeName: SR-related nuclear matrix protein of 160 kDa shortName: SRm160 alternativeName: Ser/Arg-related nuclear matrix protein
geneName	SRRM1 SRM160
identifier	Q8IYB3
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Citrullination Direct protein sequencing DNA-binding Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding Spliceosome Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	SRRM1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9000339] ENSEMBL:ENSG00000133226 SRRM1 [Homo sapiens]
secondaryIdentifier	SRRM1_HUMAN O60585 Q5VVN4
sequenceLength	904
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:249493] UniProt:Q8IYB3-2 SRRM1 [Homo sapiens] [ReferenceIsoform:410925] UniProt:Q8IYB3-1 SRRM1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:156781] SRRM1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:159255] SRRM1 [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q8IYB3 SRRM1 (249492)