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Details on Person UniProt:Q8NBT2 SPC24
| Class:Id | ReferenceGeneProduct:249016 |
|---|---|
| _chainChangeLog | chain:1-197 added on Fri February 6 2015 |
| _displayName | UniProt:Q8NBT2 SPC24 |
| _timestamp | 2024-11-03 20:21:34 |
| chain | chain:1-197 |
| checksum | C881496CA428FBDD |
| comment | FUNCTION Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).SUBUNIT Component of the NDC80 complex, which consists of NDC80/HEC1, CDCA1, SPBC24 and SPBC25. The NDC80 complex is formed by two subcomplexes composed of NDC80/HEC1-CDCA1 and SPBC24-SPBC25. Each subcomplex is formed by parallel interactions through the coiled-coil domains of individual subunits. Formation of a tetrameric complex is mediated by interactions between the C-terminal regions of both subunits of the NDC80/HEC1-CDCA1 subcomplex and the N-terminal regions of both subunits of the SPBC24-SPBC25 complex. The tetrameric NDC80 complex has an elongated rod-like structure with globular domains at either end.INTERACTION Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.ALTERNATIVE PRODUCTS Belongs to the SPC24 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Kinetochore protein Spc24 shortName: hSpc24 |
| geneName | SPC24 SPBC24 |
| identifier | Q8NBT2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Centromere Chromosome Coiled coil Kinetochore Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SPC24 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992158] ENSEMBL:ENSG00000161888 SPC24 [Homo sapiens] |
| secondaryIdentifier | SPC24_HUMAN B4DZZ7 C9JGC4 |
| sequenceLength | 197 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8964979] UniProt:Q8NBT2-1 SPC24 [Homo sapiens] [ReferenceIsoform:8964980] UniProt:Q8NBT2-2 SPC24 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:375297] SPC24 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8NBT2 SPC24 (249016)
