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Details on Person UniProt:Q9HAJ7 SAP30L
| Class:Id | ReferenceGeneProduct:248926 |
|---|---|
| _chainChangeLog | chain:1-183 added on Sat February 7 2015 |
| _displayName | UniProt:Q9HAJ7 SAP30L |
| _timestamp | 2024-11-03 20:03:20 |
| chain | chain:1-183 |
| checksum | EB19E448C6A1FA45 |
| comment | FUNCTION Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676).FUNCTION Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3.FUNCTION Functions as a transcription repressor; its activity is marginally lower than that of isoform 1.SUBUNIT Interacts with components of the histone deacetylase complex SIN3A, HDAC1 and HDAC2 (PubMed:16820529). Binds histones and nucleosomes (PubMed:19015240). Interacts with FEZ1 (PubMed:16484223).INTERACTION Detected in brain and ovary, and at lower levels in heart, small intestine, lung, kidney, skeletal muscle, stomach and spleen (at protein level) (PubMed:18070604). Ubiquitous; expressed in all tissues tested with highest levels in testis (PubMed:14680513).INDUCTION Up-regulated by TGFB1.DOMAIN The zinc-finger domain mediates direct interaction with DNA and phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) (PubMed:26609676). In vitro oxydation causes reversible disulfide bond formation between Cys residues in the zinc-finger domain and reversible loss of zinc ion binding (PubMed:26609676).SIMILARITY Belongs to the SAP30 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Histone deacetylase complex subunit SAP30L alternativeName: HCV non-structural protein 4A-transactivated protein 2 alternativeName: Sin3 corepressor complex subunit SAP30L alternativeName: Sin3-associated protein p30-like |
| geneName | SAP30L NS4ATP2 |
| identifier | Q9HAJ7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Disulfide bond DNA-binding Isopeptide bond Lipid-binding Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SAP30L |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993324] ENSEMBL:ENSG00000164576 SAP30L [Homo sapiens] |
| secondaryIdentifier | SP30L_HUMAN E9PAU7 E9PAY2 |
| sequenceLength | 183 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977625] UniProt:Q9HAJ7-1 SAP30L [Homo sapiens] [ReferenceIsoform:8977626] UniProt:Q9HAJ7-2 SAP30L [Homo sapiens] [ReferenceIsoform:8977627] UniProt:Q9HAJ7-3 SAP30L [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:351698] SAP30L [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9HAJ7 SAP30L (248926)
