Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of Collagen degradation

Class:IdPathwayDiagram:2485174
_displayNameDiagram of Collagen degradation
_timestamp2024-11-25 14:37:31
created[InstanceEdit:2485175] Jupe, S, 2012-10-01
height1270
modified[InstanceEdit:2490300] Jupe, S, 2012-10-01
[InstanceEdit:2494085] Jupe, S, 2012-10-01
[InstanceEdit:2537883] Jupe, S, 2012-10-31
[InstanceEdit:2537884] Jupe, S, 2012-10-31
[InstanceEdit:2569091] Jupe, S, 2012-11-12
[InstanceEdit:2580335] Jupe, S, 2012-11-12
[InstanceEdit:3791165] Jupe, S, 2013-07-05
[InstanceEdit:6782760] Jassal, Bijay, 2015-06-09
[InstanceEdit:6793129] Matthews, Lisa, 2015-08-31
[InstanceEdit:8942741] Jupe, Steve, 2016-10-20
[InstanceEdit:8942782] Jupe, Steve, 2016-10-20
[InstanceEdit:9032180] Jupe, Steve, 2017-12-07
[InstanceEdit:9676688] D'Eustachio, Peter, 2020-02-19
[InstanceEdit:9676934] D'Eustachio, Peter, 2020-02-24
[InstanceEdit:9929402] D'Eustachio, Peter, 2024-11-25
[InstanceEdit:9929404] D'Eustachio, Peter, 2024-11-25
representedPathway[Pathway:1442490] Collagen degradation [Homo sapiens]
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position="99 1224" bounds="42 1213 115 22" textPosition="45 1213" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Collagen type XIX</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="381" reactomeId="2537527" position="875 767" bounds="822 749 107 36" textPosition="821 749"> <Properties> <displayName>Cleaved collagen fibrils</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="391" reactomeId="2537512" position="972 697" bounds="902 685 141 24" textPosition="904 686"> <Properties> <displayName>MMP1-3, 7-9, 12, 13</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="409" reactomeId="1442481" position="979 851" bounds="950 841 58 21" textPosition="953 841"> <Properties> <displayName>MMP19</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="410" reactomeId="2564668" 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217 40" position="189 164" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="21" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="23" reactomeId="1474196" points="138 232, 197 235, 243 234" position="197 235" lineWidth="1.0"> <Inputs> <Input id="19" /> </Inputs> <Outputs> <Output id="20" /> </Outputs> <Catalysts> <Catalyst id="522" points="413 278, 246 276" /> </Catalysts> <Properties> <displayName>Collagen type II degradation by MMP14</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="24" reactomeId="2473594" points="138 223, 189 215, 243 223" position="189 215" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="19" /> </Inputs> <Outputs> <Output id="20" /> </Outputs> <Catalysts> <Catalyst id="17" points="453 187, 228 168" /> </Catalysts> <Properties> <displayName>Collagen type II degradation by MMP15</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="25" reactomeId="1474213" points="141 396, 226 411, 284 398" position="226 411" lineWidth="1.0"> <Inputs> <Input id="26" /> </Inputs> <Outputs> <Output id="27" /> </Outputs> <Catalysts> <Catalyst id="28" points="185 460" /> </Catalysts> <Properties> <displayName>Collagen type III degradation by MMP1,8,9,13</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="29" points="178 460, 218 40" position="198 250" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="28" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="30" points="175 460, 161 322" position="168 391" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="28" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction 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/> </Outputs> <Catalysts> <Catalyst id="17" points="465 204" /> </Catalysts> <Properties> <displayName>Collagen type III degradation by MMP15</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="35" reactomeId="1564142" points="148 826, 181 826, 212 826" position="181 826" lineWidth="1.0"> <Inputs> <Input id="410" /> </Inputs> <Outputs> <Output id="411" /> </Outputs> <Catalysts> <Catalyst id="38" points="180 783" /> </Catalysts> <Properties> <displayName>Collagen type IV degradation by MMP2,3,4,9,10,12</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="39" points="271 490, 184 744" position="227 617" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="32" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="40" points="179 744, 160 322" position="169 533" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="38" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="41" points="179 744, 177 494" position="178 619" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="38" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="42" points="180 744, 219 40" position="199 392" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="38" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="51" reactomeId="1564164" points="128 644, 189 643, 277 643" position="189 643" lineWidth="1.0"> <Inputs> <Input id="52" /> </Inputs> <Outputs> <Output id="53" /> </Outputs> <Catalysts> <Catalyst id="54" points="188 582" /> </Catalysts> <Properties> <displayName>Collagen type V degradation by MMP2,9,10</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="55" points="263 490, 199 548" position="231 519" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="32" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="56" points="187 582, 180 744" position="183 663" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="54" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="57" points="186 548, 178 494" position="182 521" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="54" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="58" points="188 548, 219 40" position="203 294" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="54" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="59" reactomeId="1564112" points="149 964, 185 963, 228 964" position="185 963" lineWidth="1.0"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="61" /> </Outputs> <Catalysts> <Catalyst id="62" points="184 925" /> </Catalysts> <Properties> <displayName>Collagen type VI degradation by MMP2,9,11</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="63" points="183 891, 180 783" position="181 837" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="62" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="64" points="184 891, 187 582" position="185 736" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="62" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="65" points="183 891, 177 494" position="180 692" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="62" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="66" points="184 891, 219 40" position="201 465" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="62" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="67" reactomeId="2168923" points="1476 84, 1476 117, 1476 147" position="1476 117" lineWidth="1.0"> <Inputs> <Input id="68" /> </Inputs> <Outputs> <Output id="69" points="1425 188" /> <Output id="70" points="1548 200" /> </Outputs> <Catalysts> <Catalyst id="71" points="1396 119" /> </Catalysts> <Properties> <displayName>Collagen type XVIII endostatin release</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="72" points="1292 145, 204 744" position="748 444" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="71" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="73" points="1278 145, 216 548" position="747 346" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="71" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="74" points="1298 145, 200 891" position="749 518" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="71" /> </Inputs> <Outputs> <Output id="62" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="75" points="1255 115, 291 28" position="773 71" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="71" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="76" points="1255 131, 231 294" position="743 212" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="71" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="77" points="1265 145, 213 460" position="739 302" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="71" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="78" reactomeId="2471621" points="1571 248, 1572 284, 1572 320" position="1572 284" lineWidth="1.0"> <Inputs> <Input id="70" /> </Inputs> <Catalysts> <Catalyst id="79" points="1504 287" /> </Catalysts> <Properties> <displayName>Endostatin degradation by cathepsins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="80" points="1437 258, 1339 145" position="1388 201" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="79" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="81" reactomeId="2167942" points="975 44, 1028 54, 1029 76" position="1028 54" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="82" /> </Inputs> <Outputs> <Output id="83" stoichiometry="3" points="1077 83" /> <Output id="84" points="984 82" /> </Outputs> <Properties> <displayName>Collagen type XIII ectodomain shedding</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="85" reactomeId="2168960" points="916 151, 989 205, 989 230" position="989 205" lineWidth="1.0"> <Inputs> <Input id="524" /> </Inputs> <Outputs> <Output id="87" stoichiometry="3" points="1047 249" /> <Output id="88" points="954 255" /> </Outputs> <Catalysts> <Catalyst id="89" points="966 206" /> </Catalysts> <Properties> <displayName>Collagen type XVII ectodomain shedding</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="90" reactomeId="2172405" points="942 356, 992 390, 992 420" position="992 390" lineWidth="1.0"> <Inputs> <Input id="525" /> </Inputs> <Outputs> <Output id="92" stoichiometry="3" points="1040 429" /> <Output id="93" points="967 432" /> </Outputs> <Catalysts> <Catalyst id="94" points="941 392" /> </Catalysts> <Properties> <displayName>Collagen type XXIII ectodomain shedding</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="95" reactomeId="2471842" points="959 527, 1015 547, 1016 574" position="1015 547" lineWidth="1.0"> <Inputs> <Input id="96" /> </Inputs> <Outputs> <Output id="97" stoichiometry="3" points="1053 580" /> <Output id="98" points="991 579" /> </Outputs> <Catalysts> <Catalyst id="94" points="897 407, 848 433, 845 548" /> </Catalysts> <Properties> <displayName>Collagen type XXV ectomain shedding</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="115" reactomeId="1564120" points="160 1133, 187 1132, 229 1132" position="187 1132" lineWidth="1.0"> <Inputs> <Input id="116" /> </Inputs> <Outputs> <Output id="117" /> </Outputs> <Catalysts> <Catalyst id="118" points="186 1084" /> </Catalysts> <Properties> <displayName>Collagen type VII degradation by MMP1,2,3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="119" points="185 1050, 180 783" position="182 916" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="118" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="120" points="186 1050, 187 582" position="186 816" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="118" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="121" points="199 1050, 1303 145" position="751 597" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="118" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="122" points="185 1050, 184 925" position="184 987" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="118" /> </Inputs> <Outputs> <Output id="62" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="123" points="186 1050, 219 40" position="202 545" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="118" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="124" points="185 1050, 160 322" position="172 686" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="118" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="125" points="185 1050, 177 494" position="181 772" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="118" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="126" reactomeId="1564169" points="663 861, 682 861, 712 861" position="682 861" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="127" /> </Inputs> <Outputs> <Output id="128" /> </Outputs> <Catalysts> <Catalyst id="129" points="682 800" /> </Catalysts> <Properties> <displayName>Collagen type VIII degradation by MMP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="130" points="673 763, 226 40" position="449 401" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="129" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="131" points="655 800, 205 1050" position="430 925" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="129" /> </Inputs> <Outputs> <Output id="118" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="132" points="665 763, 172 322" position="418 542" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="129" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="133" points="656 763, 195 494" position="425 628" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="129" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="134" reactomeId="2482180" points="646 883, 683 894, 722 883" position="683 894" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="127" /> </Inputs> <Outputs> <Output id="128" /> </Outputs> <Catalysts> <Catalyst id="135" points="683 934" /> </Catalysts> <Properties> <displayName>Collagen type VIII degradation by ELANE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="136" reactomeId="1564184" points="656 1059, 689 1059, 725 1059" position="689 1059" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="137" /> </Inputs> <Outputs> <Output id="138" /> </Outputs> <Catalysts> <Catalyst id="159" points="688 1095" /> </Catalysts> <Properties> <displayName>Collagen type IX degradation by MMP3,13</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="146" reactomeId="1564143" points="637 1181, 685 1194, 734 1181" position="685 1194" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="147" /> </Inputs> <Outputs> <Output id="148" /> </Outputs> <Catalysts> <Catalyst id="149" points="686 1234" /> </Catalysts> <Properties> <displayName>Collagen type X degradation by MMP1,2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="150" points="683 800, 686 1234" position="684 1017" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="129" /> </Inputs> <Outputs> <Output id="149" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="151" points="675 1234, 194 783" position="434 1008" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="149" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="152" points="670 1234, 200 925" position="435 1079" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="149" /> </Inputs> <Outputs> <Output id="62" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="153" points="679 1234, 184 494" position="431 864" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="149" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="154" points="678 1234, 196 582" position="437 908" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="149" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="155" points="682 1234, 224 40" position="453 637" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="149" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="156" points="655 1234, 216 1084" position="435 1159" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="149" /> </Inputs> <Outputs> <Output id="118" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="157" points="680 1234, 166 322" position="423 778" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="149" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="158" reactomeId="2484882" points="641 1160, 688 1161, 730 1160" position="688 1161" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="147" /> </Inputs> <Outputs> <Output id="148" /> </Outputs> <Catalysts> <Catalyst id="159" points="688 1129" /> </Catalysts> <Properties> <displayName>Collagen type X degradation by MMP3, 13</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="160" points="671 1095, 199 783" position="435 939" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="159" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="161" points="679 1095, 185 494" position="432 794" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="159" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="162" points="695 1095, 1313 145" position="1004 620" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="159" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="163" points="683 1095, 224 40" position="453 567" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="159" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="164" points="650 1109, 227 1070" position="438 1089" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="159" /> </Inputs> <Outputs> <Output id="118" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="166" points="680 1095, 167 322" position="423 708" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="159" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="182" reactomeId="1564179" points="1275 703, 1312 701, 1349 703" position="1312 701" lineWidth="1.0"> <Inputs> <Input id="183" /> </Inputs> <Outputs> <Output id="184" /> </Outputs> <Catalysts> <Catalyst id="185" points="1312 652" /> </Catalysts> <Properties> <displayName>Collagen type XI degradation by MMP1,2,3,9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="186" points="746 766, 1267 644" position="1006 705" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="129" /> </Inputs> <Outputs> <Output id="185" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="187" points="1267 639, 246 756" position="756 697" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="188" points="1267 644, 228 898" position="747 771" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="62" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="189" points="1301 652, 698 1234" position="999 943" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="149" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="190" points="1267 629, 227 483" position="747 556" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="191" points="1267 632, 232 567" position="749 599" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="192" points="1313 618, 1324 145" position="1318 381" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="193" points="1293 618, 239 40" position="766 329" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="194" points="1283 652, 215 1050" position="749 851" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="118" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="196" points="1298 652, 702 1095" position="1000 873" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="159" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="197" points="1273 618, 199 322" position="736 470" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="185" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="198" reactomeId="2168046" points="1248 834, 1303 834, 1365 834" position="1303 834" lineWidth="1.0"> <Inputs> <Input id="199" /> </Inputs> <Outputs> <Output id="200" /> </Outputs> <Catalysts> <Catalyst id="201" points="1302 797" /> </Catalysts> <Properties> <displayName>Collagen type XII degradation by MMP12</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="202" points="1272 782, 246 764" position="759 773" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="201" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="203" points="1302 769, 1324 145" position="1313 457" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="201" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="212" reactomeId="1564117" points="1375 983, 1432 983, 1476 983" position="1432 983" lineWidth="1.0"> <Inputs> <Input id="213" /> </Inputs> <Outputs> <Output id="214" /> </Outputs> <Catalysts> <Catalyst id="215" points="1431 938" /> </Catalysts> <Properties> <displayName>Collagen type XIV degradation by MMP9,13</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="216" points="1393 916, 246 770" position="819 843" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="215" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="217" points="1393 920, 228 908" position="810 914" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="215" /> </Inputs> <Outputs> <Output id="62" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="218" points="1399 904, 208 494" position="803 699" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="215" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="219" points="1426 904, 1317 652" position="1371 778" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="215" /> </Inputs> <Outputs> <Output id="185" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="220" points="1393 911, 232 575" position="812 743" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="215" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="221" points="1429 904, 1327 145" position="1378 524" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="215" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="222" points="1416 904, 234 40" position="825 472" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="215" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="224" points="1393 929, 727 1103" position="1060 1016" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="215" /> </Inputs> <Outputs> <Output id="159" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="225" points="1408 904, 182 322" position="795 613" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="215" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="279" reactomeId="2168038" points="1468 444, 1500 445, 1513 445" position="1500 445" lineWidth="1.0"> <Inputs> <Input id="280" /> </Inputs> <Outputs> <Output id="281" stoichiometry="3" points="1565 475" /> <Output id="282" points="1548 395" /> </Outputs> <Properties> <displayName>Collagen type XV restin release</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="283" reactomeId="2168982" points="1257 1126, 1296 1124, 1326 1125" position="1296 1124" lineWidth="1.0"> <Inputs> <Input id="284" /> </Inputs> <Outputs> <Output id="285" /> </Outputs> <Catalysts> <Catalyst id="286" points="1295 1088" /> </Catalysts> <Properties> <displayName>Collagen type XVI degradation by MMP9</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="287" points="1245 1055, 229 783" position="737 919" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="286" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="288" points="1237 1062, 228 913" position="732 987" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="286" /> </Inputs> <Outputs> <Output id="62" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="289" points="1269 1055, 197 494" position="733 774" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="286" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="290" points="1295 1055, 1312 652" position="1303 853" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="286" /> </Inputs> <Outputs> <Output id="185" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="291" points="1265 1055, 212 582" position="738 818" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="286" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="292" points="1295 1055, 1324 145" position="1309 600" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="286" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="293" points="1307 1055, 1420 938" position="1363 996" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="286" /> </Inputs> <Outputs> <Output id="215" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="294" reactomeId="2172433" points="160 1224, 191 1224, 216 1224" position="191 1224" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="295" /> </Inputs> <Properties> <displayName>Collagen type XIX degradation</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="380" reactomeId="1454757" points="935 756, 973 748, 1014 748" position="973 748" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="381" /> </Inputs> <Catalysts> <Catalyst id="391" points="972 715" /> </Catalysts> <Properties> <displayName>Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="382" points="1349 712, 935 760" position="1142 736" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="184" /> </Inputs> <Outputs> <Output id="381" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="383" points="319 1112, 845 791" position="582 951" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="117" /> </Inputs> <Outputs> <Output id="381" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="384" points="342 814, 816 771" position="579 792" lineWidth="0.5" lineColor="0 0 0"> <Outputs> <Output id="381" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="385" points="793 841, 855 791" position="824 816" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="128" /> </Inputs> <Outputs> <Output id="381" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="386" points="794 1139, 871 791" position="832 965" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="148" /> </Inputs> <Outputs> <Output id="381" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="387" points="399 656, 816 754" position="607 705" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="53" /> </Inputs> <Outputs> <Output id="381" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="388" points="340 946, 816 784" position="578 865" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="61" /> </Inputs> <Outputs> <Output id="381" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="389" points="323 254, 855 743" position="589 498" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="20" /> </Inputs> <Outputs> <Output id="381" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="390" points="372 113, 861 743" position="616 428" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="4" /> </Inputs> <Outputs> <Output id="381" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="392" points="1272 776, 1017 715" position="1144 745" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="201" /> </Inputs> <Outputs> <Output id="391" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="393" points="740 763, 929 715" position="834 739" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="129" /> </Inputs> <Outputs> <Output id="391" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="394" points="1283 1055, 982 715" position="1132 885" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="286" /> </Inputs> <Outputs> <Output id="391" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="395" points="958 679, 232 40" position="595 359" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="391" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="396" points="1035 679, 1267 641" position="1151 660" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="391" /> </Inputs> <Outputs> <Output id="185" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="397" points="997 715, 1407 904" position="1202 809" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="391" /> </Inputs> <Outputs> <Output id="215" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="398" points="979 679, 1313 145" position="1146 412" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="391" /> </Inputs> <Outputs> <Output id="71" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="399" points="927 679, 217 494" position="572 586" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="391" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="400" points="896 681, 232 571" position="564 626" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="391" /> </Inputs> <Outputs> <Output id="54" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="401" points="963 715, 695 1095" position="829 905" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="391" /> </Inputs> <Outputs> <Output id="159" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="402" points="896 702, 246 757" position="571 729" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="391" /> </Inputs> <Outputs> <Output id="38" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="404" points="965 715, 692 1234" position="828 974" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="391" /> </Inputs> <Outputs> <Output id="149" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="405" points="946 679, 183 322" position="564 500" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="391" /> </Inputs> <Outputs> <Output id="21" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="406" points="927 715, 228 898" position="577 806" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="391" /> </Inputs> <Outputs> <Output id="62" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="407" points="946 715, 209 1050" position="577 882" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="391" /> </Inputs> <Outputs> <Output id="118" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="408" reactomeId="2537499" points="935 770, 975 774, 1014 774" position="975 774" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="381" /> </Inputs> <Catalysts> <Catalyst id="409" points="978 838" /> </Catalysts> <Properties> <displayName>Gelatin degradation by MMP19</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="412" points="357 821, 816 772" position="586 796" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="411" /> </Inputs> <Outputs> <Output id="381" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="514" reactomeId="5696408" points="720 398, 720 433, 720 477" position="720 433" lineWidth="1.0"> <Inputs> <Input id="515" points="688 377" /> <Input id="516" points="746 376" /> </Inputs> <Outputs> <Output id="526" points="696 489" /> <Output id="521" points="720 521" /> <Output id="518" points="760 494" /> </Outputs> <Catalysts> <Catalyst id="520" points="690 433" /> </Catalysts> <Properties> <displayName>PXLP-K278-PHYKPL tetramer hydrolyses 5PHL</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Collagen degradation (2485174)
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