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Details on Person Collagen type VIII is a short chain, network-forming collage...
| Class:Id | Summation:2485139 |
|---|---|
| _displayName | Collagen type VIII is a short chain, network-forming collage... |
| _timestamp | 2012-09-28 15:56:14 |
| created | [InstanceEdit:2485082] Jupe, S, 2012-09-28 |
| literatureReference | [LiteratureReference:2168937] Type VIII collagen [LiteratureReference:2161324] Human macrophages synthesize type VIII collagen in vitro and in the atherosclerotic plaque [LiteratureReference:2167944] The primary structure of a triple-helical domain of collagen type VIII from bovine Descemet's membrane [LiteratureReference:2167984] An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis [LiteratureReference:2168931] Cleavage of type VIII collagen by human neutrophil elastase |
| text | Collagen type VIII is a short chain, network-forming collagen,thought to play a role in tissue remodeling and repair (Shuttleworth 1997, Weitkamp et al. 1999). There are two alpha chain subtypes, found in a ratio of two alpha-1 to one alpha-2 chains (Mann et al. 1990) in the typical collagen heterotrimer. Studies suggest that type VIII collagen is a major component of the hexagonal lattice seen in Descemet's membrane (Mann et al. 1990). Mutations in both alpha chains have been associated with Fuchs endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium (Jun et al. 2012). Collagen type VIII can be degraded by neutrophil elastase (ELANE, ELA2; Kittelberger et al. 1992). |
| (summation) | [Reaction:2482182] Cleavage of collagen type VIII by ELANE [Homo sapiens] |
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