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Details on Person UniProt:Q8WVK7 SKA2
| Class:Id | ReferenceGeneProduct:248413 |
|---|---|
| _chainChangeLog | chain:1-121 added on Fri February 6 2015 |
| _displayName | UniProt:Q8WVK7 SKA2 |
| _timestamp | 2024-11-03 19:48:38 |
| chain | chain:1-121 |
| checksum | D079F77E5BD4D7B0 |
| comment | FUNCTION Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).SUBUNIT Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA1; the heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with SKA1. Binds directly to microtubules; but with a much lower affinity than SKA1. May interact with NR3C1; the relevance of such interaction remains unclear in vivo.INTERACTION Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins.ALTERNATIVE PRODUCTS Belongs to the SKA2 family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Spindle and kinetochore-associated protein 2 alternativeName: Protein FAM33A |
| geneName | SKA2 FAM33A |
| identifier | Q8WVK7 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Centromere Chromosome Cytoplasm Cytoskeleton Kinetochore Microtubule Mitosis Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SKA2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991562] ENSEMBL:ENSG00000182628 SKA2 [Homo sapiens] |
| secondaryIdentifier | SKA2_HUMAN A6NIL3 B3KPL3 E9PCB8 |
| sequenceLength | 121 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976765] UniProt:Q8WVK7-1 SKA2 [Homo sapiens] [ReferenceIsoform:8976766] UniProt:Q8WVK7-2 SKA2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:376231] SKA2 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8WVK7 SKA2 (248413)
