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Details on Person UniProt:A0MZ67 Shtn1
| Class:Id | ReferenceGeneProduct:248284 |
|---|---|
| _chainChangeLog | chain:1-633 added on Sat February 7 2015 |
| _displayName | UniProt:A0MZ67 Shtn1 |
| _timestamp | 2023-11-03 17:08:05 |
| chain | chain:1-633 |
| checksum | 7E982A943E7E98C5 |
| comment | FUNCTION Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth (PubMed:17030985, PubMed:17439943, PubMed:18519736, PubMed:20664640). Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth (PubMed:18519736, PubMed:23453953). Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone (PubMed:17030985). Also plays a role in regenerative neurite outgrowth (PubMed:20664640). In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons (By similarity).SUBUNIT Interacts with PFN2. Interacts (via N-terminus) with KIF20B; this interaction is direct and promotes the association of SHTN1 to microtubules in primary neurons. Associates with microtubule (By similarity). Interacts with L1CAM; this interaction occurs in axonal growth cones (PubMed:18519736). Interacts with actin filament retrograde flow; this interaction is enhanced in a netrin-1- and PAK1-dependent manner and promotes F-actin-substrate coupling and concomitant formation of traction forces at axonal growth cones (PubMed:18519736, PubMed:23453953). Interacts with RUFY3 (PubMed:17030985).INTERACTION Localizes in multiple growth cones at neurite tips before the neuronal symmetry-breaking step (PubMed:23453953). Accumulates in growth cones of a single nascent axon in a neurite length-dependent manner during the neuronal symmetry-breaking step; when absent from the nascent axon's siblings, probably due to competitive transport, prevents the formation of surplus axons (PubMed:17030985, PubMed:23453953). Transported anterogradely from the soma to the axon growth cone in an actin and myosin-dependent manner and passively diffuses back to the cell bodies (PubMed:23453953). Colocalized with L1CAM in close apposition with actin filaments in filopodia and lamellipodia of axonal growth cones in hippocampal neurons (PubMed:18519736). Exhibits retrograde movements in filopodia and lamellopodia of axonal growth cones (PubMed:18519736). Colocalized with KIF20B along microtubules to the tip of the growing cone in primary hippocampal neurons. Recruited to the growth cone of developing axon in a KIF20B- and microtubule-dependent manner (By similarity).ALTERNATIVE PRODUCTS Brain-specific (at protein level) (PubMed:17030985). Expressed in hippocampal neurons (PubMed:18519736).DEVELOPMENTAL STAGE Expressed in hippocampal neurons at 18 dpc (PubMed:23408951). Expressed at high level both in hippocampal neurons and in brain, during the period of axon formation and elongation. Accumulates in axonal growth cones during the stage 2/3 transition. Accumulates asymmetrically in a single neurite before polarization, while it is depleted in its sibling neurites, through competitive transport to multiple neurites. Transported anterogradely to the growth cones and diffused back to the soma (at protein level) (PubMed:17030985).INDUCTION Up-regulated by axonal regeneration (PubMed:20664640).DOMAIN The N-terminus region is necessary for interaction with actin retrograde filament flow and accumulation in neuronal growth cones (PubMed:18519736).PTM Phosphorylated on Ser-101 and Ser-249 by PAK1 through a CDC42- and RAC1-dependent signaling pathway, which enhances its association with F-actin retrograde flow in filopodia and lamellipodia of axonal growth cones (PubMed:23453953). Phosphorylation on Ser-101 and Ser-249 is increased by netrin-1 (PubMed:23453953).SIMILARITY Belongs to the shootin family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: fullName evidence="13"Shootin-1 alternativeName: fullName evidence="11"Shootin1 |
| geneName | Shtn1 |
| identifier | A0MZ67 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Cell projection Coiled coil Cytoplasm Cytoskeleton Developmental protein Phosphoprotein Reference proteome |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:6791590] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Shtn1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SHOT1_RAT A0MZ64 |
| sequenceLength | 633 |
| species | [Species:48895] Rattus norvegicus |
| (isoformParent) | [ReferenceIsoform:248285] UniProt:A0MZ67-2 Shtn1 [Rattus norvegicus] [ReferenceIsoform:400730] UniProt:A0MZ67-1 Shtn1 [Rattus norvegicus] |
| (referenceEntity) | [EntityWithAccessionedSequence:443601] SHOT1_RAT [cytosol] [Rattus norvegicus] |
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No pathways have been reviewed or authored by UniProt:A0MZ67 Shtn1 (248284)
