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Details on Person UniProt:Q5FBB7 SGO1

Class:Id	ReferenceGeneProduct:248133
_chainChangeLog	chain:1-561 added on Sat February 7 2015
_displayName	UniProt:Q5FBB7 SGO1
_timestamp	2025-02-21 19:43:05
chain	chain:1-561
checksum	90CEE0FD2B40CD9C
comment	FUNCTION Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.SUBUNIT Interacts with PPP2CA (or PPP2CB), PPP2R1B, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E, SET, LRRC59, RBM10 (or RBM5), RPL10A, RPL28, RPL7, RPL7A and RPLP1. Interaction with protein phosphatase 2A occurs most probably through direct binding to the regulatory B56 subunits: PPP2R1B, PPP2R5A, PPP2R5B, PPP2R5C, PPP2R5D, PPP2R5E. Interacts with PPP2R1A and NEK2. Isoform 3 interacts with PLK1. Interacts with CDCA8.INTERACTION Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase (PubMed:16541025). Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A (PubMed:15604152, PubMed:16541025, PubMed:16580887). Colocalizes with NEK2 at the kinetochore (PubMed:17621308). Colocalizes with and SS18L1 at the kinetochore (PubMed:16582621). Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore (PubMed:17617734). Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis (PubMed:16582621). Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent (PubMed:16582621). Isoform 3 does not localize to kinetochores during any stages of the cell cycle (PubMed:16582621).ALTERNATIVE PRODUCTS Widely expressed. Highly expressed in testis. Expressed in lung, small intestine, breast, liver and placenta. Strongly overexpressed in 90% of breast cancers tested.DEVELOPMENTAL STAGE Appears in prophase cells and remains present until metaphase. Strongly decreases at the onset of anaphase and completely disappears at telophase. Not present in interphase cells (at protein level).DOMAIN The KEN box and D-box 3 are required for its ubiquitination and degradation.PTM Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1.PTM Phosphorylation by NEK2 is essential for chromosome congression in mitosis and for the proper attachment of spindle microtubule to the kinetochore. Phosphorylated by PLK1 and AUKRB.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin).SIMILARITY Belongs to the shugoshin family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: fullName evidence="25"Shugoshin 1 alternativeName: Serologically defined breast cancer antigen NY-BR-85 alternativeName: Shugoshin-like 1
geneName	SGO1 SGOL1
identifier	Q5FBB7
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cell cycle Cell division Centromere Chromosome Chromosome partition Coiled coil Cytoplasm Cytoskeleton Disease variant Kinetochore Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	SGO1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9004392] ENSEMBL:ENSG00000129810 SGO1 [Homo sapiens]
secondaryIdentifier	SGO1_HUMAN Q588H5 Q5FBB4 Q5FBB5 Q5FBB6 Q5FBB8 Q8N579 Q8WVL0 Q9BVA8 Q9H275
sequenceLength	561
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:248134] UniProt:Q5FBB7-2 SGO1 [Homo sapiens] [ReferenceIsoform:248135] UniProt:Q5FBB7-3 SGO1 [Homo sapiens] [ReferenceIsoform:248136] UniProt:Q5FBB7-4 SGO1 [Homo sapiens] [ReferenceIsoform:248137] UniProt:Q5FBB7-5 SGO1 [Homo sapiens] [ReferenceIsoform:248138] UniProt:Q5FBB7-6 SGO1 [Homo sapiens] [ReferenceIsoform:248139] UniProt:Q5FBB7-7 SGO1 [Homo sapiens] [ReferenceIsoform:407096] UniProt:Q5FBB7-1 SGO1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:376227] SGOL1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2466008] SGOL1 [chromosome, centromeric region] [Homo sapiens] [EntityWithAccessionedSequence:2468161] SGO1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9929718] p-S-SGO1 [nucleoplasm] [Homo sapiens]
(referenceSequence)	[ModifiedResidue:9929713] O-phospho-L-threonine at 346
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No pathways have been reviewed or authored by UniProt:Q5FBB7 SGO1 (248133)