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Details on Person UniProt:O75446 SAP30

Class:IdReferenceGeneProduct:247426
_chainChangeLogchain:1-220 added on Fri February 6 2015
_displayNameUniProt:O75446 SAP30
_timestamp2024-11-03 19:38:44
chainchain:1-220
checksumFF84E06B17AFCAC2
commentFUNCTION Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.FUNCTION (Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC.SUBUNIT Component of the histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2 (By similarity). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (By similarity). Interacts with HDAC1 (PubMed:9651585). Interacts with SIN3A, SIN3B, HDAC2, RBBP4 and NCOR1 (By similarity). Interacts with SAMSN1 (By similarity). Interacts with HCFC1 (PubMed:12670868). Interacts with SAP30BP (PubMed:15496587).INTERACTION Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney.SIMILARITY Belongs to the SAP30 family.
created[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
descriptionrecommendedName: Histone deacetylase complex subunit SAP30 alternativeName: 30 kDa Sin3-associated polypeptide alternativeName: Sin3 corepressor complex subunit SAP30 alternativeName: Sin3-associated polypeptide p30
geneNameSAP30
identifierO75446
isSequenceChangedFALSE
keyword3D-structure
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
nameSAP30
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:9002626] ENSEMBL:ENSG00000164105 SAP30 [Homo sapiens]
secondaryIdentifierSAP30_HUMAN
D3DP38
sequenceLength220
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:351693] SAP30 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O75446 SAP30 (247426)
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