Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:Q8WUX1 SLC38A5

Class:Id	ReferenceGeneProduct:247152
_chainChangeLog	chain:1-472 added on Sat February 7 2015
_displayName	UniProt:Q8WUX1 SLC38A5
_timestamp	2025-02-21 19:32:26
chain	chain:1-472
checksum	2DDB4C03E5E78734
comment	FUNCTION Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:11243884). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate-glutamine cycle (By similarity). The transport activity is pH sensitive and Li(+) tolerant (PubMed:11243884). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity).CATALYTIC ACTIVITY L-serine(out) + Na(+)(out) + H(+)(in) = L-serine(in) + Na(+)(in) + H(+)(out)CATALYTIC ACTIVITY L-alanine(out) + Na(+)(out) + H(+)(in) = L-alanine(in) + Na(+)(in) + H(+)(out)CATALYTIC ACTIVITY glycine(out) + Na(+)(out) + H(+)(in) = glycine(in) + Na(+)(in) + H(+)(out)CATALYTIC ACTIVITY L-glutamine(out) + Na(+)(out) + H(+)(in) = L-glutamine(in) + Na(+)(in) + H(+)(out)CATALYTIC ACTIVITY L-asparagine(out) + Na(+)(out) + H(+)(in) = L-asparagine(in) + Na(+)(in) + H(+)(out)CATALYTIC ACTIVITY L-histidine(out) + Na(+)(out) + H(+)(in) = L-histidine(in) + Na(+)(in) + H(+)(out)CATALYTIC ACTIVITY L-cysteine(out) + Na(+)(out) + H(+)(in) = L-cysteine(in) + Na(+)(in) + H(+)(out)ACTIVITY REGULATION Not inhibited by lithium (PubMed:11243884). Partial allosteric regulation on ions sodium binding (By similarity).BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 8.0.SUBCELLULAR LOCATION Localized at astroglial membrane.ALTERNATIVE PRODUCTS Predominantly expressed in stomach, brain, liver, lung and intestinal tract.SIMILARITY Belongs to the amino acid/polyamine transporter 2 family.CAUTION Nakanishi et al (PubMed:11243884) shows that the transport process is electrogenic, contrary to the conclusions of Hamdani et al (PMID:11742981) who finds that the transport is electroneutral with a Na(+):L-glutamine stoichiometry of 1:1 (PubMed:11243884). Hamdani et al (PMID:11742981) shows that this electrogenic transport describes by Nakanishi et al. would correspond to large uncoupled fluxes of protons (PubMed:11243884).
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
description	recommendedName: fullName evidence="8"Sodium-coupled neutral amino acid transporter 5 alternativeName: Solute carrier family 38 member 5 alternativeName: System N transporter 2
geneName	SLC38A5 JM24 SN2 SNAT5 PP7194
identifier	Q8WUX1
isSequenceChanged	FALSE
keyword	Acetylation Alternative splicing Cell membrane Disulfide bond Glycoprotein Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	SLC38A5
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9000297] ENSEMBL:ENSG00000017483 SLC38A5 [Homo sapiens]
secondaryIdentifier	S38A5_HUMAN B3KT20 B5MDE6 B7WPJ9 Q6PIW9 Q8WYU2 Q96PQ4
sequenceLength	472
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:247153] UniProt:Q8WUX1-2 SLC38A5 [Homo sapiens] [ReferenceIsoform:412097] UniProt:Q8WUX1-1 SLC38A5 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:352167] SLC38A5 [plasma membrane] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:Q8WUX1 SLC38A5 (247152)