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Details on Person As inferred from mouse, Activin binds the Activin receptor c...
| Class:Id | Summation:2470473 |
|---|---|
| _displayName | As inferred from mouse, Activin binds the Activin receptor c... |
| _timestamp | 2023-08-21 15:23:56 |
| created | [InstanceEdit:2470496] May, B, 2012-09-18 |
| literatureReference | [LiteratureReference:9840171] Inhibin is an antagonist of bone morphogenetic protein signaling [LiteratureReference:9842165] Betaglycan binds inhibin and can mediate functional antagonism of activin signalling |
| modified | [InstanceEdit:2484921] May, B, 2012-09-26 [InstanceEdit:9842163] Tiwari, Krishna, 2023-08-21 [InstanceEdit:9842173] Orlic-Milacic, Marija, 2023-08-21 |
| text | As inferred from mouse, Activin binds the Activin receptor composed of a type II receptor (ACVR2A/B) and a type I receptor, in this case ACVR1C (ALK7). It is unclear if the type II receptor and the type I receptor are associated before binding Activin. Activin AB (INHBA:INHBB) and Activin B (INHBB:INHBB), but not Activin A (INHBA:INHBA) can bind and signal via an activin receptor containing the ACVR1C (ALK7) type I receptor. Also, TGFBR3 (Betaglycan) antagonises Activin signalling by binding with Inhibin A and ACVR2A (ActRII). TGFBR3 and Activin compete for ACVR2A and TGFBR3 thus inhibits activin signalling (Lewis et al. 2000, Waiter et al. 2003). |
| (summation) | [Reaction:2470483] Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C [Homo sapiens] |
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