Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Diagram of Visual phototransduction, Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D), Biosynthesis of A2E, implicated in retinal degradation, Defective visual phototransduction due to ABCA4 loss of function, Defective visual phototransduction due to LRAT loss of function, Defective visual phototransduction due to OPN1LW loss of function, Defective visual phototransduction due to OPN1MW loss of function, Defective visual phototransduction due to OPN1SW loss of function, Defective visual phototransduction due to RDH12 loss of function, Defective visual phototransduction due to RDH5 loss of function, and Defective visual phototransduction due to STRA6 loss of function
| Class:Id | PathwayDiagram:2468358 |
|---|---|
| _displayName | Diagram of Visual phototransduction, Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D), Biosynthesis of A2E, implicated in retinal degradation, Defective visual phototransduction due to ABCA4 loss of function, Defective visual phototransduction due to LRAT loss of function, Defective visual phototransduction due to OPN1LW loss of function, Defective visual phototransduction due to OPN1MW loss of function, Defective visual phototransduction due to OPN1SW loss of function, Defective visual phototransduction due to RDH12 loss of function, Defective visual phototransduction due to RDH5 loss of function, and Defective visual phototransduction due to STRA6 loss of function |
| _timestamp | 2026-02-20 15:49:28 |
| created | [InstanceEdit:2468359] Jassal, B, 2012-09-17 |
| height | 1413 |
| modified | [InstanceEdit:2470272] Jassal, Bijay, 2012-09-18 [InstanceEdit:2470325] Jassal, Bijay, 2012-09-18 [InstanceEdit:2471974] Jassal, B, 2012-09-21 [InstanceEdit:2473613] Jassal, Bijay, 2012-09-24 [InstanceEdit:2474796] Jassal, B, 2012-09-25 [InstanceEdit:2477159] Jassal, B, 2012-09-25 [InstanceEdit:2479676] Jassal, B, 2012-09-25 [InstanceEdit:2482239] Jassal, B, 2012-09-25 [InstanceEdit:2482240] Wu, G, 2012-09-25 [InstanceEdit:2485181] Jassal, Bijay, 2012-10-01 [InstanceEdit:2487741] Jassal, B, 2012-10-01 [InstanceEdit:2497674] Jassal, B, 2012-10-01 [InstanceEdit:2514885] Jassal, B, 2012-10-11 [InstanceEdit:2517888] Jassal, B, 2012-10-11 [InstanceEdit:2534412] Jassal, Bijay, 2012-10-26 [InstanceEdit:2534430] Jassal, B, 2012-10-26 [InstanceEdit:2581516] Jassal, Bijay, 2012-11-13 [InstanceEdit:2632502] Jassal, Bijay, 2012-11-21 [InstanceEdit:2649000] Jassal, Bijay, 2012-11-23 [InstanceEdit:2652726] Jassal, B, 2012-11-23 [InstanceEdit:2657086] Jassal, B, 2012-11-23 [InstanceEdit:2677934] Jassal, B, 2012-11-28 [InstanceEdit:2855255] Jassal, B, 2012-12-18 [InstanceEdit:2859060] Jassal, B, 2012-12-19 [InstanceEdit:2864105] Jassal, Bijay, 2012-12-19 [InstanceEdit:3189826] Jassal, B, 2013-02-25 [InstanceEdit:3222185] Jassal, Bijay, 2013-03-18 [InstanceEdit:3234113] Jassal, Bijay, 2013-03-27 [InstanceEdit:3270623] Jassal, B, 2013-04-11 [InstanceEdit:3544441] Jassal, B, 2013-05-20 [InstanceEdit:4084694] Gillespie, ME, 2013-07-30 [InstanceEdit:4127424] Gillespie, ME, 2013-08-14 [InstanceEdit:5153513] Jassal, B, 2013-11-21 [InstanceEdit:5159254] Jassal, B, 2013-11-22 [InstanceEdit:5164398] Jassal, Bijay, 2013-11-25 [InstanceEdit:5168516] Jassal, B, 2013-11-25 [InstanceEdit:5173345] Jassal, B, 2013-11-28 [InstanceEdit:5177468] Jassal, Bijay, 2013-11-28 [InstanceEdit:5181589] Jassal, B, 2013-11-28 [InstanceEdit:5205898] Jassal, B, 2013-12-06 [InstanceEdit:5211379] Jassal, B, 2013-12-10 [InstanceEdit:5250619] Jassal, B, 2014-01-29 [InstanceEdit:5357424] Jassal, B, 2014-03-21 [InstanceEdit:5358714] Jassal, Bijay, 2014-04-03 [InstanceEdit:5362140] Jassal, Bijay, 2014-04-15 [InstanceEdit:5362527] Jassal, Bijay, 2014-04-16 [InstanceEdit:5615664] Jassal, Bijay, 2014-07-28 [InstanceEdit:5626263] Jassal, Bijay, 2014-10-09 [InstanceEdit:5658112] Jassal, Bijay, 2014-12-17 [InstanceEdit:5684872] Jassal, Bijay, 2015-03-23 [InstanceEdit:6786732] Jassal, Bijay, 2015-07-10 [InstanceEdit:6792737] Matthews, Lisa, 2015-08-26 [InstanceEdit:6793944] Jassal, Bijay, 2015-09-04 [InstanceEdit:6807236] Jassal, Bijay, 2015-10-30 [InstanceEdit:6809582] Jassal, Bijay, 2015-11-12 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:8951018] Jassal, Bijay, 2016-12-02 [InstanceEdit:8951572] Jassal, Bijay, 2016-12-08 [InstanceEdit:8960977] Jassal, Bijay, 2017-02-02 [InstanceEdit:8961789] Jassal, Bijay, 2017-02-06 [InstanceEdit:8961790] Jassal, Bijay, 2017-02-06 [InstanceEdit:8979812] Jassal, Bijay, 2017-02-27 [InstanceEdit:8980133] Jassal, Bijay, 2017-02-27 [InstanceEdit:8981406] Jassal, Bijay, 2017-03-07 [InstanceEdit:9016827] Jassal, Bijay, 2017-08-16 [InstanceEdit:9026304] Jupe, Steve, 2017-10-19 [InstanceEdit:9034629] D'Eustachio, Peter, 2018-01-08 [InstanceEdit:9036717] Jassal, Bijay, 2018-02-07 [InstanceEdit:9635406] Jassal, Bijay, 2019-02-04 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9645316] Matthews, Lisa, 2019-05-08 [InstanceEdit:9656889] Jassal, Bijay, 2019-08-06 [InstanceEdit:9656890] Jassal, Bijay, 2019-08-06 [InstanceEdit:9656892] Jassal, Bijay, 2019-08-06 [InstanceEdit:9667077] Wu, G, 2019-11-07 [InstanceEdit:9684094] D'Eustachio, Peter, 2020-04-20 [InstanceEdit:9685724] D'Eustachio, Peter, 2020-04-27 [InstanceEdit:9686582] D'Eustachio, Peter, 2020-05-04 [InstanceEdit:9696549] D'Eustachio, Peter, 2020-07-22 [InstanceEdit:9697271] Jassal, Bijay, 2020-08-12 [InstanceEdit:9697368] D'Eustachio, Peter, 2020-08-13 [InstanceEdit:9698130] Jassal, Bijay, 2020-08-24 [InstanceEdit:9698205] D'Eustachio, Peter, 2020-08-24 [InstanceEdit:9698274] Jassal, Bijay, 2020-08-25 [InstanceEdit:9698372] Matthews, Lisa, 2020-08-25 [InstanceEdit:9763818] D'Eustachio, Peter, 2022-02-04 [InstanceEdit:9910917] D'Eustachio, Peter, 2024-05-23 [InstanceEdit:9918468] Orlic-Milacic, Marija, 2024-08-15 [InstanceEdit:9919076] Orlic-Milacic, Marija, 2024-08-19 [InstanceEdit:9982703] D'Eustachio, Peter, 2026-02-18 [InstanceEdit:9982901] D'Eustachio, Peter, 2026-02-20 |
| representedPathway | [Pathway:2187338] Visual phototransduction [Homo sapiens] [Pathway:5619077] Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) [Homo sapiens] [Pathway:2466712] Biosynthesis of A2E, implicated in retinal degradation [Homo sapiens] [Pathway:9918454] Defective visual phototransduction due to ABCA4 loss of function [Homo sapiens] [Pathway:9918442] Defective visual phototransduction due to LRAT loss of function [Homo sapiens] [Pathway:9918450] Defective visual phototransduction due to OPN1LW loss of function [Homo sapiens] [Pathway:9918436] Defective visual phototransduction due to OPN1MW loss of function [Homo sapiens] [Pathway:9918443] Defective visual phototransduction due to OPN1SW loss of function [Homo sapiens] [Pathway:9918440] Defective visual phototransduction due to RDH12 loss of function [Homo sapiens] [Pathway:9918438] Defective visual phototransduction due to RDH5 loss of function [Homo sapiens] [Pathway:9918449] Defective visual phototransduction due to STRA6 loss of function [Homo sapiens] |
| storedATXML | <?xml version="1.0" encoding="UTF-8"?> <Process nextId="6426" reactomeDiagramId="2468358"> <Properties> <displayName>Diagram of Visual phototransduction, Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D), Biosynthesis of A2E, implicated in retinal degradation, Defective visual phototransduction due to ABCA4 loss of function, Defective visual phototransduction due to LRAT loss of function, Defective visual phototransduction due to OPN1LW loss of function, Defective visual phototransduction due to OPN1MW loss of function, Defective visual phototransduction due to OPN1SW loss of function, Defective visual phototransduction due to RDH12 loss of function, Defective visual phototransduction due to RDH5 loss of function, and Defective visual phototransduction due to STRA6 loss of function</displayName> </Properties> <Nodes> <org.gk.render.RenderableComplex id="246" reactomeId="2453705" position="235 882" bounds="182 871 107 22" textPosition="183 871" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TTR:RBP4:atROL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="259" reactomeId="70101" position="606 462" bounds="229 105 754 715" textPosition="754 470" bgColor="250 240 240" lineColor="255 153 102" insets="238 116 735 693"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="289" /> <Component id="268" /> <Component id="276" /> <Component id="293" /> <Component id="296" /> <Component id="299" /> <Component id="319" /> <Component id="320" /> <Component id="324" /> <Component id="326" /> <Component id="330" /> <Component id="295" /> <Component id="314" /> <Component id="316" /> <Component id="328" /> <Component id="335" /> <Component id="338" /> <Component id="345" /> <Component id="287" /> <Component id="297" /> <Component id="334" /> <Component id="333" /> <Component id="261" /> <Component id="262" /> <Component id="265" /> <Component id="260" /> <Component id="264" /> <Component id="271" /> <Component id="780" /> <Component id="992" /> <Component id="2468" /> <Component id="2479" /> <Component id="2526" /> <Component id="5130" /> <Component id="5131" /> <Component id="5132" /> <Component id="5135" /> <Component id="5129" /> <Component id="5137" /> <Component id="5139" /> <Component id="5141" /> <Component id="5387" /> <Component id="5392" /> <Component id="5479" /> <Component id="5481" /> <Component id="5483" /> <Component id="5827" /> <Component id="6419" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="261" reactomeId="2453826" position="231 781" bounds="208 770 47 22" textPosition="208 770"> <Properties> <displayName>STRA6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="262" reactomeId="2453850" position="394 816" bounds="340 798 109 36" textPosition="340 798" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TTR:RBP4:atROL:STRA6</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="265" reactomeId="2453860" position="595 816" bounds="541 805 109 22" textPosition="541 805" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TTR:RBP4:STRA6</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="271" reactomeId="74841" position="443 713" bounds="423 702 41 22" textPosition="424 702" /> <org.gk.render.RenderableProtein id="282" reactomeId="975606" position="402 524" bounds="383 513 39 22" textPosition="383 513"> <Properties> <displayName>LRAT</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="287" reactomeId="17957" position="466 487" bounds="394 441 144 93" textPosition="408 457" bgColor="250 240 240" lineColor="255 153 102" insets="405 453 124 70"> <Components> <Component id="282" /> <Component id="5133" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="289" reactomeId="13977" position="324 372" bounds="253 308 143 129" textPosition="294 363" bgColor="250 240 240" lineColor="255 153 102" insets="262 317 126 112"> <Properties> <displayName>lipid droplet</displayName> </Properties> <Components> <Component id="5825" /> <Component id="5828" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="295" reactomeId="30927" position="340 197" bounds="309 182 62 30" textPosition="313 186" /> <org.gk.render.RenderableProtein id="296" reactomeId="74853" position="225 299" bounds="201 286 49 26" textPosition="202 288"> <Properties> <displayName>RPE65</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.3469387755102041" relativeY="0.0" label="Pa" trackId="0" reactomeId="2453906" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="297" reactomeId="2454121" position="269 234" bounds="244 223 51 22" textPosition="244 223"> <Properties> <displayName>MYO7A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="299" reactomeId="70106" position="364 242" bounds="346 227 36 30" textPosition="350 231" /> <org.gk.render.RenderableComplex id="316" reactomeId="2454078" position="499 182" bounds="451 171 97 22" textPosition="453 171" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableComplex id="320" reactomeId="2454060" position="777 178" bounds="729 167 96 22" textPosition="731 167" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RLBP1:11cRAL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="321" reactomeId="2454066" position="619 217" bounds="584 206 71 22" textPosition="584 206"> <Properties> <displayName>RDH10,11</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="324" reactomeId="70106" position="665 139" bounds="647 124 36 30" textPosition="651 128" /> <org.gk.render.RenderableChemical id="326" reactomeId="29364" position="718 147" bounds="689 132 59 30" textPosition="693 136" /> <org.gk.render.RenderableChemical id="328" reactomeId="29366" position="550 145" bounds="520 130 60 30" textPosition="524 134" /> <org.gk.render.RenderableCompartment id="330" reactomeId="17957" position="634 266" bounds="535 211 198 110" textPosition="534 249" bgColor="250 240 240" lineColor="255 153 102" insets="543 220 183 93"> <Properties> <displayName>endoplasmic reticulum lumen</displayName> </Properties> <Components> <Component id="321" /> <Component id="4611" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="334" reactomeId="29360" position="491 392" bounds="465 377 53 30" textPosition="469 381"> <Properties> <displayName>NAD+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="335" reactomeId="73473" position="705 408" bounds="679 393 52 30" textPosition="683 397"> <Properties> <displayName>NADH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="338" reactomeId="70106" position="743 376" bounds="725 361 36 30" textPosition="729 365" /> <org.gk.render.RenderableChemical id="342" reactomeId="32737" position="1101 234" bounds="1071 219 61 30" textPosition="1075 223" /> <org.gk.render.Note id="345" position="781 466" bounds="756 455 50 22" textPosition="766 455"> <Properties> <isChanged>true</isChanged> <displayName>RPE</displayName> </Properties> </org.gk.render.Note> <org.gk.render.RenderableCompartment id="348" reactomeId="70101" position="2071 468" bounds="1031 72 2080 792" textPosition="2302 539" bgColor="250 240 240" lineColor="255 153 102" insets="1042 82 2061 772"> <Components> <Component id="342" /> <Component id="383" /> <Component id="384" /> <Component id="385" /> <Component id="386" /> <Component id="389" /> <Component id="382" /> <Component id="397" /> <Component id="404" /> <Component id="411" /> <Component id="458" /> <Component id="651" /> <Component id="391" /> <Component id="730" /> <Component id="726" /> <Component id="731" /> <Component id="736" /> <Component id="737" /> <Component id="742" /> <Component id="743" /> <Component id="744" /> <Component id="746" /> <Component id="764" /> <Component id="398" /> <Component id="993" /> <Component id="1001" /> <Component id="1002" /> <Component id="1007" /> <Component id="1004" /> <Component id="1017" /> <Component id="1020" /> <Component id="1031" /> <Component id="1030" /> <Component id="1077" /> <Component id="1075" /> <Component id="1079" /> <Component id="1080" /> <Component id="1084" /> <Component id="1097" /> <Component id="1158" /> <Component id="1159" /> <Component id="1210" /> <Component id="1078" /> <Component id="1246" /> <Component id="1250" /> <Component id="1251" /> <Component id="1248" /> <Component id="1019" /> <Component id="1339" /> <Component id="1344" /> <Component id="1354" /> <Component id="1355" /> <Component id="1357" /> <Component id="1359" /> <Component id="1365" /> <Component id="1383" /> <Component id="1390" /> <Component id="1400" /> <Component id="408" /> <Component id="991" /> <Component id="1022" /> <Component id="1023" /> <Component id="1038" /> <Component id="1406" /> <Component id="1381" /> <Component id="1382" /> <Component id="1395" /> <Component id="1393" /> <Component id="1387" /> <Component id="1386" /> <Component id="406" /> <Component id="2605" /> <Component id="2609" /> <Component id="4603" /> <Component id="4608" /> <Component id="4609" /> <Component id="4610" /> <Component id="4612" /> <Component id="4876" /> <Component id="4878" /> <Component id="4888" /> <Component id="4890" /> <Component id="4891" /> <Component id="4910" /> <Component id="4938" /> <Component id="4943" /> <Component id="1035" /> <Component id="1036" /> <Component id="1045" /> <Component id="1027" /> <Component id="1021" /> <Component id="4601" /> <Component id="5144" /> <Component id="5146" /> <Component id="5192" /> <Component id="5193" /> <Component id="5194" /> <Component id="5196" /> <Component id="5473" /> <Component id="5472" /> <Component id="5475" /> <Component id="5476" /> <Component id="5477" /> <Component id="5474" /> <Component id="5821" /> <Component id="5824" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableProtein id="350" reactomeId="419802" position="1105 306" bounds="1088 295 35 22" textPosition="1088 295"> <Properties> <displayName>RHO</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="364" reactomeId="2466098" position="1726 423" bounds="1701 408 50 30" textPosition="1705 412" /> <org.gk.render.RenderableChemical id="383" reactomeId="113592" position="1729 479" bounds="1709 464 40 30" textPosition="1713 468" /> <org.gk.render.RenderableChemical id="384" reactomeId="29356" position="1732 516" bounds="1711 501 43 30" textPosition="1715 505" /> <org.gk.render.RenderableChemical id="385" reactomeId="29370" position="1656 581" bounds="1636 566 41 30" textPosition="1640 570" /> <org.gk.render.RenderableChemical id="386" reactomeId="29372" position="1703 592" bounds="1690 577 27 30" textPosition="1694 581" /> <org.gk.render.RenderableProtein id="387" reactomeId="1457539" position="1661 421" bounds="1637 410 48 22" textPosition="1637 410"> <Properties> <displayName>ABCA4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="389" reactomeId="975622" position="1788 602" bounds="1763 587 50 30" textPosition="1767 591" /> <org.gk.render.RenderableProtein id="398" reactomeId="2464787" position="2205 856" bounds="2180 845 51 22" textPosition="2180 845"> <Properties> <displayName>RDH12</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="404" reactomeId="70106" position="1877 730" bounds="1859 715 36 30" textPosition="1863 719" /> <org.gk.render.RenderableChemical id="406" reactomeId="29364" position="1852 685" bounds="1823 670 59 30" textPosition="1827 674"> <Properties> <displayName>NADPH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="408" reactomeId="29366" position="1881 780" bounds="1851 765 60 30" textPosition="1855 769" /> <org.gk.render.Note id="458" position="1334 733" bounds="1277 717 115 33" textPosition="1300 716"> <Properties> <isChanged>true</isChanged> <displayName>Rod outer segment</displayName> </Properties> </org.gk.render.Note> <org.gk.render.RenderableCompartment id="504" reactomeId="70101" position="549 1201" bounds="213 999 672 404" textPosition="598 1205" bgColor="250 240 240" lineColor="255 153 102" insets="221 1009 653 383"> <Components> <Component id="517" /> <Component id="516" /> <Component id="526" /> <Component id="529" /> <Component id="530" /> <Component id="506" /> <Component id="533" /> <Component id="534" /> <Component id="535" /> <Component id="536" /> <Component id="540" /> <Component id="541" /> <Component id="542" /> <Component id="546" /> <Component id="548" /> <Component id="980" /> <Component id="982" /> <Component id="5467" /> <Component id="5469" /> <Component id="5471" /> <Component id="5823" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.Note id="506" position="629 1201" bounds="581 1185 96 32" textPosition="596 1190"> <Properties> <isChanged>true</isChanged> <displayName>Muller cell</displayName> </Properties> </org.gk.render.Note> <org.gk.render.RenderableComplex id="517" reactomeId="2465956" position="669 1047" bounds="626 1036 87 22" textPosition="628 1036" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RLBP1:atROL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="527" reactomeId="2465932" position="584 1099" bounds="527 1088 114 22" textPosition="531 1088"> <Properties> <displayName>atROL isomerase</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableComplex id="529" reactomeId="2454078" position="397 1045" bounds="349 1034 97 22" textPosition="351 1034" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RLBP1:11cROL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="530" reactomeId="17957" position="590 1128" bounds="451 1092 279 73" textPosition="529 1110" bgColor="250 240 240" lineColor="255 153 102" insets="458 1099 263 58"> <Components> <Component id="527" /> <Component id="5468" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="534" reactomeId="200993" position="325 1079" bounds="286 1064 78 30" textPosition="290 1068"> <Properties> <displayName>PALM-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="535" reactomeId="76194" position="338 1159" bounds="307 1144 62 30" textPosition="311 1148"> <Properties> <displayName>CoA-SH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="536" reactomeId="2465964" position="543 1291" bounds="504 1276 78 30" textPosition="508 1280"> <Properties> <displayName>11cRPALM</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="541" reactomeId="29356" position="546 1336" bounds="525 1321 43 30" textPosition="529 1325" /> <org.gk.render.RenderableEntity id="542" reactomeId="2466001" position="639 1394" bounds="623 1383 33 22" textPosition="623 1383"> <Properties> <displayName>REH</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableChemical id="546" reactomeId="76168" position="765 1332" bounds="741 1317 48 30" textPosition="745 1321"> <Properties> <displayName>PALM</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="548" reactomeId="70106" position="731 1366" bounds="713 1351 36 30" textPosition="717 1355" /> <org.gk.render.RenderableCompartment id="551" reactomeId="70101" position="1556 1182" bounds="969 1007 1175 351" textPosition="992 1079" bgColor="250 240 240" lineColor="255 153 102" insets="979 1015 1155 335"> <Components> <Component id="565" /> <Component id="575" /> <Component id="570" /> <Component id="577" /> <Component id="579" /> <Component id="620" /> <Component id="621" /> <Component id="626" /> <Component id="628" /> <Component id="630" /> <Component id="598" /> <Component id="977" /> <Component id="983" /> <Component id="2529" /> <Component id="5199" /> <Component id="5201" /> <Component id="616" /> <Component id="5466" /> <Component id="573" /> <Component id="566" /> <Component id="581" /> <Component id="5478" /> <Component id="5480" /> <Component id="5482" /> <Component id="5485" /> <Component id="5487" /> <Component id="5489" /> <Component id="5486" /> <Component id="5488" /> <Component id="5490" /> <Component id="5528" /> <Component id="5798" /> <Component id="5800" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableEntity id="566" reactomeId="2465962" position="1151 1241" bounds="1123 1230 57 22" textPosition="1123 1230"> <Properties> <displayName>11cRDH</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableChemical id="570" reactomeId="29366" position="1098 1324" bounds="1068 1309 60 30" textPosition="1072 1313" /> <org.gk.render.RenderableChemical id="573" reactomeId="29364" position="1212 1321" bounds="1183 1306 59 30" textPosition="1187 1310" /> <org.gk.render.RenderableChemical id="575" reactomeId="70106" position="1214 1251" bounds="1196 1236 36 30" textPosition="1200 1240"> <Properties> <displayName>H+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableCompartment id="577" reactomeId="17957" position="1183 1125" bounds="1119 1085 128 81" textPosition="1124 1103" bgColor="250 240 240" lineColor="255 153 102" insets="1128 1094 111 61"> <Components> <Component id="635" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableEntitySet id="580" reactomeId="2466081" position="1408 1160" bounds="1351 1149 114 22" textPosition="1354 1149"> <Properties> <displayName>Cone apo-opsins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="581" reactomeId="2466099" position="1820 1270" bounds="1765 1252 111 36" textPosition="1765 1252" bgColor="204 255 255"> <Properties> <displayName>11c-retinyl-cone opsins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="599" reactomeId="2466087" position="1943 1135" bounds="1892 1118 102 35" textPosition="1893 1118" bgColor="204 255 255"> <Properties> <displayName>at-retinyl-cone opsins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="620" reactomeId="975622" position="1563 1063" bounds="1538 1048 50 30" textPosition="1542 1052" /> <org.gk.render.RenderableChemical id="626" reactomeId="29366" position="1345 1098" bounds="1315 1083 60 30" textPosition="1319 1087" /> <org.gk.render.RenderableChemical id="628" reactomeId="29364" position="1510 1090" bounds="1481 1075 59 30" textPosition="1485 1079" /> <org.gk.render.RenderableChemical id="630" reactomeId="70106" position="1506 1030" bounds="1488 1015 36 30" textPosition="1492 1019" /> <org.gk.render.Note id="635" position="1047 1076" bounds="974 1061 146 30" textPosition="985 1065"> <Properties> <isChanged>true</isChanged> <displayName>Cone outer segment</displayName> </Properties> </org.gk.render.Note> <org.gk.render.RenderableChemical id="651" reactomeId="2466859" position="1505 853" bounds="1481 838 48 30" textPosition="1485 842" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" lineWidth="1.0" isForDisease="true" /> <org.gk.render.RenderableChemical id="730" reactomeId="2466716" position="1738 736" bounds="1714 721 48 30" textPosition="1718 725" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>NRPE</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="736" reactomeId="2466738" position="1228 854" bounds="1205 839 47 30" textPosition="1209 843" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" lineWidth="1.0" isForDisease="true"> <Properties> <displayName>A2PE</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="737" reactomeId="29356" position="1245 766" bounds="1224 751 43 30" textPosition="1228 755" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" lineWidth="1.0" /> <org.gk.render.RenderableProtein id="739" reactomeId="1457539" position="1659 701" bounds="1635 690 48 22" textPosition="1635 690" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0" /> <org.gk.render.RenderableChemical id="741" reactomeId="2466098" position="1475 704" bounds="1450 689 50 30" textPosition="1454 693" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" lineWidth="1.0"> <Properties> <displayName>atRAL</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="742" reactomeId="29372" position="1760 821" bounds="1747 806 27 30" textPosition="1751 810" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0" /> <org.gk.render.RenderableChemical id="743" reactomeId="29370" position="1765 783" bounds="1745 768 41 30" textPosition="1749 772" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="744" reactomeId="113592" position="1601 773" bounds="1581 758 40 30" textPosition="1585 762" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0" /> <org.gk.render.RenderableChemical id="746" reactomeId="29356" position="1571 803" bounds="1550 788 43 30" textPosition="1554 792" bgColor="204 255 204" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0" /> <org.gk.render.RenderableProtein id="764" reactomeId="2467460" position="1155 853" bounds="1123 842 65 22" textPosition="1125 842" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" lineWidth="1.0"> <Properties> <displayName>NAPEPLD</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="776" reactomeId="263698" position="1101 926" bounds="1035 879 132 95" textPosition="1044 926" bgColor="250 240 240" lineColor="255 153 102" insets="1047 888 109 74"> <Properties> <displayName>phagolysosome</displayName> </Properties> <Components> <Component id="778" /> <Component id="4906" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="778" reactomeId="2467755" position="1115 921" bounds="1095 906 40 30" textPosition="1099 910" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" lineWidth="1.0" isForDisease="true" /> <org.gk.render.RenderableChemical id="780" reactomeId="2467742" position="885 782" bounds="865 767 40 30" textPosition="869 771" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" lineWidth="1.0" isForDisease="true"> <Properties> <displayName>A2E</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="977" reactomeId="2473611" position="1051 1284" bounds="1020 1269 62 30" textPosition="1024 1273"> <Properties> <displayName>11cROL</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="980" reactomeId="2473606" position="787 1268" bounds="756 1253 62 30" textPosition="760 1257" /> <org.gk.render.RenderableChemical id="982" reactomeId="2473617" position="827 1046" bounds="802 1031 51 30" textPosition="806 1035" /> <org.gk.render.RenderableChemical id="983" reactomeId="2473607" position="1308 1046" bounds="1283 1031 51 30" textPosition="1287 1035"> <Properties> <displayName>atROL</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="991" reactomeId="2473615" position="1891 824" bounds="1866 809 51 30" textPosition="1870 813" /> <org.gk.render.RenderableChemical id="992" reactomeId="2473604" position="513 749" bounds="488 734 51 30" textPosition="492 738" /> <org.gk.render.Note id="993" position="2332 809" bounds="2295 791 75 36" textPosition="2298 791"> <Properties> <isChanged>true</isChanged> <displayName>Rod inner segment</displayName> </Properties> </org.gk.render.Note> <org.gk.render.RenderableComplex id="1000" reactomeId="74063" position="1473 306" bounds="1446 295 54 22" textPosition="1446 295" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Gt-GDP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1001" reactomeId="29438" position="1505 272" bounds="1485 257 41 30" textPosition="1489 261" /> <org.gk.render.RenderableChemical id="1002" reactomeId="29420" position="1617 271" bounds="1596 256 42 30" textPosition="1600 260"> <Properties> <displayName>GDP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1003" reactomeId="74064" position="1627 305" bounds="1601 294 53 22" textPosition="1601 294" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>Gt-GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1005" reactomeId="74061" position="1751 302" bounds="1707 291 89 22" textPosition="1707 291" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GNB1:GNGT1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1006" reactomeId="74049" position="1861 301" bounds="1820 290 82 22" textPosition="1820 290" bgColor="204 255 255" lineWidth="1.0" hideComponents="true"> <Properties> <displayName>GNAT1-GTP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableCompartment id="1007" reactomeId="2514888" position="2034 362" bounds="1072 302 1924 121" textPosition="2311 332" bgColor="250 240 240" lineColor="255 153 102"> <Components> <Component id="1051" /> <Component id="1335" /> <Component id="1343" /> <Component id="1346" /> <Component id="1348" /> <Component id="1353" /> <Component id="1360" /> <Component id="349" /> <Component id="5143" /> <Component id="5808" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="1009" reactomeId="74055" position="1935 302" bounds="1914 291 42 22" textPosition="1915 291" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PDE6</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1010" reactomeId="74056" position="2131 308" bounds="2073 297 117 22" textPosition="2073 297" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GNAT1-GTP:PDE6</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1019" reactomeId="29356" position="2284 234" bounds="2263 219 43 30" textPosition="2267 223" /> <org.gk.render.RenderableChemical id="1020" reactomeId="113578" position="2069 197" bounds="2014 175 110 44" textPosition="2052 186"> <Properties> <displayName>GMP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1022" reactomeId="74011" position="2849 77" bounds="2786 66 127 22" textPosition="2790 66" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>cGMP:CNG channel</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1023" reactomeId="74001" position="3043 79" bounds="2999 68 89 22" textPosition="3002 68" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CNG channel</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1028" reactomeId="74113" position="2722 26" bounds="2701 11 43 30" textPosition="2705 15" /> <org.gk.render.RenderableChemical id="1029" reactomeId="74112" position="2794 26" bounds="2769 11 50 30" textPosition="2773 15" /> <org.gk.render.RenderableChemical id="1030" reactomeId="83910" position="2684 112" bounds="2663 97 43 30" textPosition="2667 101" /> <org.gk.render.RenderableChemical id="1031" reactomeId="74016" position="2943 189" bounds="2918 174 50 30" textPosition="2922 178" /> <org.gk.render.RenderableChemical id="1036" reactomeId="29804" position="3049 364" bounds="3032 349 35 30" textPosition="3036 353" /> <org.gk.render.RenderableChemical id="1037" reactomeId="74126" position="3173 261" bounds="3156 246 35 30" textPosition="3160 250"> <Properties> <displayName>K+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="1038" reactomeId="74129" position="3107 385" bounds="3076 374 63 22" textPosition="3077 374"> <Properties> <displayName>SLC24A1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1040" reactomeId="74113" position="3212 318" bounds="3191 303 43 30" textPosition="3195 307"> <Properties> <displayName>Na+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1045" reactomeId="83910" position="3037 294" bounds="3016 279 43 30" textPosition="3020 283" /> <org.gk.render.RenderableChemical id="1047" reactomeId="74112" position="3209 375" bounds="3184 360 50 30" textPosition="3188 364" /> <org.gk.render.RenderableCompartment id="1051" reactomeId="2514888" position="2034 361" bounds="1081 310 1906 103" textPosition="2035 337" bgColor="250 240 240" lineColor="255 153 102"> <Components> <Component id="1082" /> <Component id="1161" /> <Component id="1247" /> <Component id="1249" /> <Component id="1008" /> <Component id="1345" /> <Component id="1347" /> <Component id="1349" /> <Component id="364" /> <Component id="387" /> <Component id="350" /> <Component id="1005" /> <Component id="1006" /> <Component id="1009" /> <Component id="1010" /> <Component id="1362" /> <Component id="1363" /> <Component id="1384" /> <Component id="1385" /> <Component id="1391" /> <Component id="1000" /> <Component id="1003" /> <Component id="1388" /> <Component id="1389" /> <Component id="4911" /> <Component id="4913" /> <Component id="4942" /> <Component id="5142" /> <Component id="999" /> <Component id="4912" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="1077" reactomeId="174390" position="1256 618" bounds="1231 603 51 30" textPosition="1235 607"> <Properties> <displayName>L-Met</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="1078" reactomeId="2534043" position="1294 536" bounds="1252 518 84 36" textPosition="1252 518"> <Properties> <displayName>GNAT1 (Met removed)</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableEntitySet id="1079" reactomeId="2534069" position="1160 627" bounds="1125 616 71 22" textPosition="1125 616" bgColor="204 255 255"> <Properties> <displayName>METAP1/2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="1082" reactomeId="2534062" position="1420 416" bounds="1361 405 118 22" textPosition="1361 405" lineWidth="1.0"> <Properties> <displayName>N-(C14:0)-GNAT1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1483050847457627" relativeY="0.0" label="My" trackId="0" reactomeId="2534018" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1084" reactomeId="76194" position="1495 473" bounds="1464 458 62 30" textPosition="1468 462" /> <org.gk.render.RenderableEntitySet id="1097" reactomeId="2649003" position="1374 455" bounds="1345 444 58 22" textPosition="1345 444"> <Properties> <displayName>NMT1/2</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1159" reactomeId="2534017" position="1345 600" bounds="1315 589 61 22" textPosition="1315 589"> <Properties> <displayName>acyl-CoA</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1161" reactomeId="2534054" position="1564 415" bounds="1516 404 96 22" textPosition="1516 404" lineWidth="1.0"> <Properties> <displayName>N-acyl-GNAT1</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="1210" reactomeId="2565915" position="1089 585" bounds="1064 574 51 22" textPosition="1064 574"> <Properties> <displayName>GNAT1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1247" reactomeId="55393" position="1089 416" bounds="1063 405 52 22" textPosition="1063 405"> <Properties> <displayName>GNGT1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1248" reactomeId="2530486" position="1080 465" bounds="1062 450 37 30" textPosition="1066 454"> <Properties> <displayName>FPP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="1249" reactomeId="2530520" position="1218 417" bounds="1171 406 95 22" textPosition="1171 406"> <Properties> <displayName>S-farn-GNGT1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.17894736842105263" relativeY="0.0" label="Fn" trackId="0" reactomeId="2530499" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1250" reactomeId="111294" position="1198 485" bounds="1181 470 34 30" textPosition="1185 474"> <Properties> <displayName>PPi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1251" reactomeId="2530496" position="1139 517" bounds="1102 506 74 22" textPosition="1102 506" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FNTA:FNTB</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1339" reactomeId="63140" position="1889 499" bounds="1847 488 85 22" textPosition="1847 488"> <Properties> <displayName>S-farn-GRK1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.2" relativeY="0.0" label="Fn" trackId="0" reactomeId="2581491" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1344" reactomeId="50320" position="2077 473" bounds="2060 462 34 22" textPosition="2061 462"> <Properties> <displayName>SAG</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1345" reactomeId="2581511" position="2201 413" bounds="2168 397 66 32" textPosition="2168 407" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-MII:SAG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1347" reactomeId="2632519" position="2337 417" bounds="2299 406 77 22" textPosition="2299 406" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-RHO:SAG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1349" reactomeId="2581504" position="2519 417" bounds="2461 399 117 36" textPosition="2461 399"> <Properties> <displayName>p-S334,338,343-RHO</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.13675213675213677" relativeY="0.0" label="P" description="Ser" trackId="0" reactomeId="2581505" /> <org.gk.render.RenderableFeature relativeX="0.27350427350427353" relativeY="0.0" label="P" description="Ser" trackId="0" reactomeId="2581506" /> <org.gk.render.RenderableFeature relativeX="0.41025641025641024" relativeY="0.0" label="P" description="Ser" trackId="0" reactomeId="2581507" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1354" reactomeId="29356" position="2575 467" bounds="2554 452 43 30" textPosition="2558 456"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1355" reactomeId="2632510" position="2653 533" bounds="2609 522 88 22" textPosition="2612 522" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PPEF1:Mg2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1357" reactomeId="29372" position="2757 458" bounds="2744 443 27 30" textPosition="2748 447" /> <org.gk.render.RenderableChemical id="1359" reactomeId="74016" position="2721 490" bounds="2696 475 50 30" textPosition="2700 479"> <Properties> <displayName>Ca2+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="1362" reactomeId="74062" position="2012 305" bounds="1971 294 83 22" textPosition="1971 294" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GNAT1-GDP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1363" reactomeId="74601" position="2352 306" bounds="2304 288 96 36" textPosition="2304 288" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RGS9-1:GNB5:RGS9BP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="1365" reactomeId="29372" position="2000 234" bounds="1987 219 27 30" textPosition="1991 223"> <Properties> <displayName>Pi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1382" reactomeId="113592" position="2347 237" bounds="2327 222 40 30" textPosition="2331 226"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1383" reactomeId="29370" position="2551 247" bounds="2531 232 41 30" textPosition="2535 236" /> <org.gk.render.RenderableComplex id="1384" reactomeId="2648990" position="2553 305" bounds="2498 287 111 36" textPosition="2498 287" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p-S478-RGS9-1:GNB5:RGS9BP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1385" reactomeId="2648977" position="2449 307" bounds="2418 296 63 22" textPosition="2418 296"> <Properties> <displayName>PRKCA/Q</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1388" reactomeId="2586735" position="2916 307" bounds="2895 296 42 22" textPosition="2895 296"> <Properties> <displayName>GUCA</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1389" reactomeId="2586734" position="2811 304" bounds="2771 293 81 22" textPosition="2772 293" bgColor="204 255 255"> <Properties> <displayName>GUCA:Ca2+</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1391" reactomeId="74883" position="2728 304" bounds="2704 293 49 22" textPosition="2705 293"> <Properties> <displayName>GUCYs</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="1393" reactomeId="29438" position="2807 257" bounds="2787 242 41 30" textPosition="2791 246"> <Properties> <displayName>GTP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1395" reactomeId="111294" position="2624 257" bounds="2607 242 34 30" textPosition="2611 246" /> <org.gk.render.RenderableChemical id="1400" reactomeId="30991" position="2634 196" bounds="2610 181 49 30" textPosition="2614 185"> <Properties> <displayName>cGMP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="2468" reactomeId="74841" position="260 512" bounds="240 501 41 22" textPosition="241 501"> <Properties> <displayName>RBP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="2479" reactomeId="2864101" position="333 749" bounds="293 738 81 22" textPosition="295 738" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RBP1:atROL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="2526" reactomeId="2984237" position="366 142" bounds="343 131 47 22" textPosition="344 131"> <Properties> <displayName>RLBP1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2527" reactomeId="2984190" position="934 1154" bounds="914 1143 41 22" textPosition="915 1143"> <Properties> <displayName>RBP3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2529" reactomeId="2980986" position="1442 1010" bounds="1417 999 51 22" textPosition="1418 999"> <Properties> <displayName>DHRS3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="2530" reactomeId="2984190" position="1004 157" bounds="984 146 41 22" textPosition="985 146" /> <org.gk.render.RenderableProtein id="2532" reactomeId="2984190" position="1006 770" bounds="986 759 41 22" textPosition="987 759" /> <org.gk.render.RenderableCompartment id="2599" reactomeId="2514888" position="1537 672" bounds="1307 644 461 56" textPosition="1310 655" bgColor="250 240 240" lineColor="255 153 102"> <Components> <Component id="739" /> <Component id="741" /> <Component id="2603" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="2603" reactomeId="3234112" position="1537 703" bounds="1522 688 31 30" textPosition="1526 692" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 51" lineWidth="1.0"> <Properties> <displayName>PE</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="2605" reactomeId="74016" position="1842 459" bounds="1817 444 50 30" textPosition="1821 448" /> <org.gk.render.RenderableCompartment id="2609" reactomeId="2514888" position="1537 672" bounds="1301 638 472 69" textPosition="1310 655" bgColor="250 240 240" lineColor="255 153 102"> <Properties> <displayName>photoreceptor disc membrane</displayName> </Properties> <Components> <Component id="2599" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableComplex id="4603" reactomeId="3229184" position="3108 214" bounds="3048 196 120 36" textPosition="3048 196" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CALM1:Ca2+:CNG channel</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="4609" reactomeId="3229219" position="1845 549" bounds="1802 538 87 22" textPosition="1802 538" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RCVRN:Ca2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="4610" reactomeId="3229193" position="1998 589" bounds="1954 571 89 36" textPosition="1954 571" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>S-farn-GRK1:RCVRN:Ca2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="4611" reactomeId="4084692" position="625 316" bounds="565 298 121 36" textPosition="565 298"> <Properties> <displayName>RDH5(1-318)-like Proteins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="4612" reactomeId="4127419" position="1809 862" bounds="1747 851 124 22" textPosition="1749 851"> <Properties> <displayName>RDH8-like proteins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableChemical id="4890" reactomeId="432659" position="1081 762" bounds="1065 747 32 30" textPosition="1069 751" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 51 51" lineWidth="1.0"> <Properties> <displayName>PA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="4891" reactomeId="2466848" position="1061 851" bounds="1041 836 40 30" textPosition="1045 840" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0" lineWidth="1.0" isForDisease="true" /> <org.gk.render.RenderableChemical id="4910" reactomeId="29356" position="2220 452" bounds="2199 437 43 30" textPosition="2203 441" /> <org.gk.render.RenderableProtein id="4911" reactomeId="5205900" position="1251 308" bounds="1198 297 106 22" textPosition="1198 297"> <Properties> <displayName>11c-retinyl-RHO</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1509433962264151" relativeY="0.0" label="Rt" trackId="0" reactomeId="5205905" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="4912" reactomeId="29356" position="1218 353" bounds="1197 338 43 30" textPosition="1201 342" /> <org.gk.render.RenderableProtein id="4913" reactomeId="5205901" position="1389 305" bounds="1342 294 95 22" textPosition="1342 294"> <Properties> <displayName>at-retinyl-RHO</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.16842105263157894" relativeY="0.0" label="Rt" trackId="0" reactomeId="5205904" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="4938" reactomeId="113592" position="1791 444" bounds="1771 429 40 30" textPosition="1775 433" /> <org.gk.render.RenderableProtein id="4942" reactomeId="5205903" position="2024 420" bounds="1966 402 117 36" textPosition="1966 402"> <Properties> <displayName>p-S334,338,343-at-retinyl-RHO</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.13675213675213677" relativeY="0.0" label="P" trackId="0" reactomeId="2581505" /> <org.gk.render.RenderableFeature relativeX="0.27350427350427353" relativeY="0.0" label="P" trackId="0" reactomeId="2581506" /> <org.gk.render.RenderableFeature relativeX="0.41025641025641024" relativeY="0.0" label="P" trackId="0" reactomeId="2581507" /> <org.gk.render.RenderableFeature relativeX="0.5470085470085471" relativeY="0.0" label="Rt" trackId="0" reactomeId="5205899" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="4943" reactomeId="29370" position="1969 465" bounds="1949 450 41 30" textPosition="1953 454" /> <org.gk.render.RenderableChemical id="5130" reactomeId="6786220" position="393 583" bounds="372 568 43 30" textPosition="376 572"> <Properties> <displayName>DHA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5131" reactomeId="6786225" position="689 586" bounds="608 560 163 52" textPosition="665 575"> <Properties> <displayName>HDoHE</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5132" reactomeId="29356" position="608 550" bounds="587 535 43 30" textPosition="591 539" /> <org.gk.render.RenderableProtein id="5133" reactomeId="6786215" position="521 527" bounds="494 516 55 22" textPosition="494 516"> <Properties> <displayName>CYP4V2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="5135" reactomeId="29368" position="407 622" bounds="390 607 34 30" textPosition="394 611"> <Properties> <displayName>O2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5137" reactomeId="29364" position="455 628" bounds="426 613 59 30" textPosition="430 617" /> <org.gk.render.RenderableChemical id="5139" reactomeId="70106" position="443 559" bounds="425 544 36 30" textPosition="429 548" /> <org.gk.render.RenderableChemical id="5141" reactomeId="29366" position="601 625" bounds="571 610 60 30" textPosition="575 614"> <Properties> <displayName>NADP+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="5142" reactomeId="6787798" position="1868 339" bounds="1835 328 66 22" textPosition="1835 328"> <Properties> <displayName>GRK1,4,7</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="5146" reactomeId="74294" position="2998 129" bounds="2948 118 101 22" textPosition="2948 118" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CALM1:4xCa2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="5193" reactomeId="71284" position="2999 606" bounds="2969 591 61 30" textPosition="2973 595"> <Properties> <displayName>AdoMet</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5194" reactomeId="71285" position="2837 621" bounds="2807 606 61 30" textPosition="2811 610"> <Properties> <displayName>AdoHcy</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="5196" reactomeId="6786199" position="2910 502" bounds="2877 491 66 23" textPosition="2880 491"> <Properties> <displayName>CAMKMT</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="5197" reactomeId="975634" position="76 884" bounds="13 846 127 76" textPosition="20 855"> <Properties> <displayName>Retinoid metabolism and transport</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableCompartment id="5199" reactomeId="2514888" position="1707 1158" bounds="1370 1134 674 49" textPosition="1510 1141" bgColor="250 240 240" lineColor="255 153 102"> <Components> <Component id="580" /> <Component id="599" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="5201" reactomeId="29356" position="1769 1088" bounds="1748 1073 43 30" textPosition="1752 1077" /> <org.gk.render.RenderableChemical id="5387" reactomeId="8960974" position="919 217" bounds="889 202 61 30" textPosition="893 206"> <Properties> <displayName>11cRAL</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5466" reactomeId="32737" position="1285 1283" bounds="1255 1268 61 30" textPosition="1259 1272" /> <org.gk.render.RenderableComplex id="5467" reactomeId="8981408" position="397 1201" bounds="342 1190 110 22" textPosition="342 1190" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>RLBP1:11cRPALM</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="5468" reactomeId="8848506" position="460 1115" bounds="435 1104 51 22" textPosition="435 1104"> <Properties> <displayName>AWAT2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="5471" reactomeId="2984237" position="362 1328" bounds="339 1317 47 22" textPosition="340 1317" /> <org.gk.render.RenderableProtein id="5472" reactomeId="9016707" position="3013 545" bounds="2988 534 50 22" textPosition="2989 534"> <Properties> <displayName>CALM1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="5473" reactomeId="9016706" position="2773 561" bounds="2717 550 112 22" textPosition="2717 550"> <Properties> <displayName>Me3K116-CALM1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.16071428571428573" relativeY="0.0" label="Me" trackId="0" reactomeId="6786206" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="5474" reactomeId="55479" position="2693 223" bounds="2664 212 59 22" textPosition="2665 212"> <Properties> <displayName>GUCA1B</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="5475" reactomeId="55477" position="2730 196" bounds="2700 185 61 22" textPosition="2702 185"> <Properties> <displayName>GUCA1A</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="5476" reactomeId="75340" position="2807 184" bounds="2764 173 86 22" textPosition="2764 173" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GCAP2:Ca2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="5477" reactomeId="75339" position="2836 212" bounds="2793 201 86 22" textPosition="2793 201" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>GCAP1:Ca2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="5478" reactomeId="391835" position="1329 1240" bounds="1298 1229 62 22" textPosition="1298 1229"> <Properties> <displayName>OPN1MW</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="5480" reactomeId="419772" position="1511 1198" bounds="1482 1187 58 22" textPosition="1482 1187"> <Properties> <displayName>OPN1SW</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="5482" reactomeId="419769" position="1430 1228" bounds="1401 1217 58 22" textPosition="1401 1217"> <Properties> <displayName>OPN1LW</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="5485" reactomeId="5211266" position="1642 1276" bounds="1588 1265 109 22" textPosition="1588 1265"> <Properties> <displayName>11cRAL-OPN1LW</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.14678899082568808" relativeY="0.0" label="Rt" trackId="0" reactomeId="5211264" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="5487" reactomeId="5211257" position="1642 1311" bounds="1588 1300 109 22" textPosition="1588 1300"> <Properties> <displayName>11cRAL-OPN1SW</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.14678899082568808" relativeY="0.0" label="Rt" trackId="0" reactomeId="5211254" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="5489" reactomeId="5211258" position="1641 1241" bounds="1585 1230 113 22" textPosition="1585 1230"> <Properties> <displayName>11cRAL-OPN1MW</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.1415929203539823" relativeY="0.0" label="Rt" trackId="0" reactomeId="5211261" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="5528" reactomeId="29356" position="1528 1329" bounds="1507 1314 43 30" textPosition="1511 1318" /> <org.gk.render.RenderableChemical id="5807" reactomeId="419777" position="1882 1388" bounds="1855 1377 54 22" textPosition="1858 1377"> <Properties> <displayName>Photon</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5810" reactomeId="419777" position="1316 32" bounds="1289 21 54 22" textPosition="1292 21" /> <org.gk.render.RenderableEntity id="5821" reactomeId="2565924" position="1437 526" bounds="1393 515 89 22" textPosition="1393 515"> <Properties> <displayName>unknown NAT</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableProtein id="5823" reactomeId="2984237" position="791 1090" bounds="768 1079 47 22" textPosition="769 1079" /> <org.gk.render.RenderableChemical id="5824" reactomeId="184174" position="1278 470" bounds="1243 455 70 31" textPosition="1247 459"> <Properties> <displayName>MYS-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5825" reactomeId="9982476" position="295 403" bounds="274 388 43 31" textPosition="278 392"> <Properties> <displayName>atRE</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5827" reactomeId="29356" position="425 379" bounds="404 364 43 31" textPosition="408 368" /> <org.gk.render.RenderableChemical id="5828" reactomeId="9982478" position="348 341" bounds="319 326 58 31" textPosition="323 330"> <Properties> <displayName>RCOO-</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="6419" reactomeId="9982900" position="236 627" bounds="207 612 58 31" textPosition="211 616" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="260" reactomeId="2453876" points="288 816, 288 816, 337 816" position="288 816" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="246" points="243 868" /> <Input id="261" points="248 795" /> </Inputs> <Outputs> <Output id="262" /> </Outputs> <Properties> <displayName>TTR:RBP:atROL binds to STRA6 receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="264" reactomeId="2453863" points="452 816, 486 816, 512 816" position="486 816" lineWidth="1.0"> <Inputs> <Input id="262" /> </Inputs> <Outputs> <Output id="265" points="538 816" /> <Output id="992" points="512 767" /> </Outputs> <Properties> <displayName>STRA6 transports atROL from extracellular region to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="268" reactomeId="74843" points="410 749, 409 749, 377 749" position="409 749" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="992" points="485 749" /> <Input id="271" points="432 727" /> </Inputs> <Outputs> <Output id="2479" /> </Outputs> <Properties> <displayName>atROL binds RBP1 to form RBP1:atROL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="276" reactomeId="2453855" points="331 637, 330 544, 315 484" position="330 544" lineWidth="1.0"> <Inputs> <Input id="6419" points="268 630" /> <Input id="2479" points="332 735" /> </Inputs> <Outputs> <Output id="5825" points="298 422" /> <Output id="2468" points="284 501" /> </Outputs> <Catalysts> <Catalyst id="282" points="380 529" /> </Catalysts> <Properties> <displayName>LRAT esterifies RBP1:atROL and FACYLs to atREs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="293" reactomeId="2453833" points="301 355, 300 298, 315 259" position="300 298" lineWidth="1.0"> <Inputs> <Input id="5827" points="401 374" /> <Input id="5825" points="296 385" /> </Inputs> <Outputs> <Output id="295" points="333 215" /> <Output id="5828" points="341 323" /> <Output id="299" points="343 248" /> </Outputs> <Catalysts> <Catalyst id="296" points="253 298" /> </Catalysts> <Activators> <Activator id="297" points="274 248" /> </Activators> <Properties> <displayName>RPE65 isomero-hydrolyses atREs to 11cROL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="314" reactomeId="2454264" points="414 181, 414 180, 448 180" position="414 180" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="295" points="374 190" /> <Input id="2526" points="379 156" /> </Inputs> <Outputs> <Output id="316" /> </Outputs> <Properties> <displayName>11cROL binds to RLBP1 to form RLBP1:11cROL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="319" reactomeId="74872" points="588 178, 617 178, 652 178" position="617 178" lineWidth="1.0"> <Inputs> <Input id="316" points="551 179" /> <Input id="328" points="567 163" /> </Inputs> <Outputs> <Output id="320" points="726 178" /> <Output id="324" points="660 157" /> <Output id="326" points="686 160" /> </Outputs> <Catalysts> <Catalyst id="321" points="618 200" /> </Catalysts> <Properties> <displayName>RDH10,11 oxidise 11cROL to 11cRAL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="333" reactomeId="2454081" points="529 363, 625 363, 698 363" position="625 363" lineWidth="1.0"> <Inputs> <Input id="334" points="510 374" /> <Input id="316" points="500 196" /> </Inputs> <Outputs> <Output id="335" points="702 390" /> <Output id="320" points="774 192, 748 316" /> <Output id="338" points="722 370" /> </Outputs> <Catalysts> <Catalyst id="4611" points="625 340" /> </Catalysts> <Properties> <displayName>RDH5 oxidises 11cROL to 11cRAL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="341" reactomeId="2454113" points="953 216, 1004 216, 1068 228" position="1004 216" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="5387" /> </Inputs> <Outputs> <Output id="342" /> </Outputs> <Catalysts> <Catalyst id="2530" points="1004 171" /> </Catalysts> <Properties> <displayName>RBP3 transports 11cRAL to rod photoreceptor outer segment</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="349" reactomeId="2454118" points="1140 305, 1158 305, 1176 305" position="1158 305" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="350" points="1126 305" /> <Input id="342" points="1109 252" /> </Inputs> <Outputs> <Output id="4911" points="1195 305" /> <Output id="4912" points="1204 335" /> </Outputs> <Properties> <displayName>11cRAL binds to opsin to form 11c-retinyl:RHO</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="382" reactomeId="1467466" points="1687 487, 1661 487, 1681 542" position="1661 487" lineWidth="1.0"> <Inputs> <Input id="364" points="1716 441" /> <Input id="383" points="1706 482" /> <Input id="384" points="1708 502" /> </Inputs> <Outputs> <Output id="385" points="1665 563" /> <Output id="386" points="1696 574" /> <Output id="389" points="1760 587" /> </Outputs> <Catalysts> <Catalyst id="387" points="1661 435" /> </Catalysts> <Properties> <displayName>ABCA4 mediates atRAL transport</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="391" reactomeId="2464810" points="1736 441, 1789 510, 1788 584" position="1789 510" lineWidth="1.0"> <Inputs> <Input id="364" /> </Inputs> <Outputs> <Output id="389" /> </Outputs> <Properties> <displayName>atRAL(membrane) diffuses to atRAL(cytosol)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="397" reactomeId="2464822" points="1901 655, 1921 722, 1931 759" position="1921 722" lineWidth="1.0"> <Inputs> <Input id="404" points="1881 712" /> <Input id="406" points="1876 667" /> <Input id="389" points="1816 613" /> </Inputs> <Outputs> <Output id="991" points="1900 806" /> <Output id="408" points="1914 767" /> </Outputs> <Catalysts> <Catalyst id="398" points="2181 842" /> </Catalysts> <Properties> <displayName>RDH12 reduces atRAL to atROL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="411" reactomeId="2464803" points="1787 681, 1812 744, 1824 772" position="1812 744" lineWidth="1.0"> <Inputs> <Input id="389" points="1787 620" /> <Input id="404" points="1856 720" /> <Input id="406" points="1820 683" /> </Inputs> <Outputs> <Output id="991" points="1871 806" /> <Output id="408" points="1848 775" /> </Outputs> <Catalysts> <Catalyst id="4612" points="1809 845" /> </Catalysts> <Properties> <displayName>RDH8 reduces atRAL to atROL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="447" reactomeId="2464809" points="1889 842, 1878 986, 1004 986, 1004 805, 938 749, 542 749" position="1004 805" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="991" /> </Inputs> <Outputs> <Output id="992" /> </Outputs> <Catalysts> <Catalyst id="2532" points="1005 784" /> </Catalysts> <Properties> <displayName>RBP3 regulates the transport of atROL from ROS to RPE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="508" reactomeId="2465938" points="1280 1046, 936 1046, 856 1046" position="936 1046" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="983" /> </Inputs> <Outputs> <Output id="982" /> </Outputs> <Catalysts> <Catalyst id="2527" points="934 1140" /> </Catalysts> <Properties> <displayName>RBP3 regulates atROL taken up by Muller cells</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="516" reactomeId="2465971" points="772 1045, 746 1046, 716 1046" position="746 1046" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="982" points="799 1045" /> <Input id="5823" points="786 1076" /> </Inputs> <Outputs> <Output id="517" /> </Outputs> <Properties> <displayName>RLBP1 binds atROL to form RLBP1:atROL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="526" reactomeId="2465926" points="623 1045, 584 1045, 449 1045" position="584 1045" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="517" /> </Inputs> <Outputs> <Output id="529" /> </Outputs> <Catalysts> <Catalyst id="527" points="584 1085" /> </Catalysts> <Properties> <displayName>An atROL isomerase isomerises atROL to 11cROL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="533" reactomeId="2465919" points="396 1086, 396 1115, 396 1149" position="396 1115" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="534" points="367 1082" /> <Input id="529" points="396 1059" /> </Inputs> <Outputs> <Output id="535" points="372 1153" /> <Output id="5467" points="396 1187" /> </Outputs> <Catalysts> <Catalyst id="5468" points="432 1115" /> </Catalysts> <Properties> <displayName>AWAT2 transfers PALM to 11cROL forming 11cRPALM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="540" reactomeId="2465941" points="602 1321, 639 1322, 680 1322" position="639 1322" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="536" points="572 1309" /> <Input id="541" points="571 1330" /> </Inputs> <Outputs> <Output id="980" points="757 1286" /> <Output id="548" points="713 1348" /> <Output id="546" points="738 1329" /> </Outputs> <Catalysts> <Catalyst id="542" points="639 1380" /> </Catalysts> <Properties> <displayName>A REH hydrolyses 11cRE to 11cROL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="552" reactomeId="2465934" points="821 1267, 936 1267, 1017 1279" position="936 1267" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="980" /> </Inputs> <Outputs> <Output id="977" /> </Outputs> <Catalysts> <Catalyst id="2527" points="934 1168" /> </Catalysts> <Properties> <displayName>11cROL translocates from Muller cells to cone photoreceptor cells</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="565" reactomeId="2465921" points="1125 1283, 1152 1283, 1184 1283" position="1152 1283" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="977" points="1085 1283" /> <Input id="570" points="1107 1306" /> </Inputs> <Outputs> <Output id="575" points="1199 1269" /> <Output id="573" points="1200 1303" /> <Output id="5466" points="1252 1283" /> </Outputs> <Catalysts> <Catalyst id="566" points="1151 1255" /> </Catalysts> <Properties> <displayName>11cRDH oxidises 11cROL to 11cRAL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="579" reactomeId="2465924" points="1410 1283, 1460 1283, 1509 1283" position="1410 1283" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5482" points="1426 1242" /> <Input id="5466" points="1319 1283" /> </Inputs> <Outputs> <Output id="5485" points="1585 1278" /> <Output id="5528" points="1521 1311" /> </Outputs> <Properties> <displayName>OPN1LW binds 11cRAL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="598" reactomeId="2465917" points="1945 1270, 1945 1220, 1943 1159" position="1945 1220" lineWidth="1.0"> <Inputs> <Input id="581" points="1882 1270" /> <Input id="5807" points="1887 1374" /> </Inputs> <Outputs> <Output id="599" /> </Outputs> <Properties> <displayName>Photons induce isomerisation of 11c-retinyl to at-retinyl</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="616" reactomeId="2466085" points="1709 1121, 1677 1121, 1613 1121" position="1677 1121" lineWidth="1.0"> <Inputs> <Input id="599" points="1886 1131" /> <Input id="5201" points="1745 1099" /> </Inputs> <Outputs> <Output id="580" points="1471 1149" /> <Output id="620" points="1575 1081" /> </Outputs> <Properties> <displayName>at-retinyl is hydrolysed from R* to release atRAL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="621" reactomeId="2465940" points="1480 1062, 1442 1062, 1371 1062" position="1442 1062" lineWidth="1.0"> <Inputs> <Input id="620" points="1535 1062" /> <Input id="628" points="1493 1072" /> <Input id="630" points="1493 1048" /> </Inputs> <Outputs> <Output id="983" points="1337 1052" /> <Output id="626" points="1355 1080" /> </Outputs> <Catalysts> <Catalyst id="2529" points="1442 1024" /> </Catalysts> <Properties> <displayName>atRAL is reduced to atROL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="726" reactomeId="2466749" points="1631 818, 1659 818, 1687 818" position="1659 818" lineWidth="1.0" lineColor="0 0 0"> <Inputs> <Input id="744" points="1611 791" /> <Input id="746" points="1596 808" /> <Input id="651" points="1532 846" /> </Inputs> <Outputs> <Output id="730" points="1728 754" /> <Output id="742" points="1744 820" /> <Output id="743" points="1742 792" /> </Outputs> <Catalysts> <Catalyst id="739" points="1659 715" /> </Catalysts> <Properties> <displayName>ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="731" reactomeId="2466718" points="1733 718, 1711 636, 1712 636" position="1711 636" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="730" /> </Inputs> <Outputs> <Output id="2603" points="1556 697" /> <Output id="389" points="1760 613" /> </Outputs> <Properties> <displayName>NRPE dissociates to atRAL and PE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="999" reactomeId="2485180" points="1519 305, 1544 314, 1568 305" position="1544 314" lineWidth="1.0"> <Inputs> <Input id="1001" points="1511 290" /> <Input id="1000" points="1503 305" /> </Inputs> <Outputs> <Output id="1002" points="1593 285" /> <Output id="1003" points="1598 305" /> </Outputs> <Catalysts> <Catalyst id="4913" points="1421 319, 1485 338" /> </Catalysts> <Inhibitors> <Inhibitor id="1345" points="2165 408" /> <Inhibitor id="4942" points="1963 411, 1543 349" /> </Inhibitors> <Properties> <displayName>MII catalyses GDP/GTP exchange on Gt</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1004" reactomeId="2485182" points="1657 299, 1685 293, 1685 293" position="1685 293" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="1003" /> </Inputs> <Outputs> <Output id="1005" points="1730 316, 1712 323" /> <Output id="1006" points="1817 293, 1736 277" /> </Outputs> <Properties> <displayName>Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1008" reactomeId="74065" points="1975 345, 1976 345, 2084 322" position="1976 345" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1006" points="1889 315" /> <Input id="1009" points="1945 316" /> </Inputs> <Outputs> <Output id="1010" /> </Outputs> <Inhibitors> <Inhibitor id="1362" points="2002 319" /> </Inhibitors> <Properties> <displayName>GNAT1-GTP binds PDE6 and activates it</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1017" reactomeId="74059" points="2313 196, 2130 196, 2127 196" position="2130 196" lineWidth="1.0"> <Inputs> <Input id="1019" points="2295 216" /> <Input id="1400" points="2607 196" /> </Inputs> <Outputs> <Output id="1020" /> </Outputs> <Catalysts> <Catalyst id="1010" points="2130 294" /> </Catalysts> <Properties> <displayName>PDE6 hydrolyses cGMP to GMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1021" reactomeId="2514865" points="2916 76, 2960 76, 2961 78" position="2960 76" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="1022" /> </Inputs> <Outputs> <Output id="1023" points="2996 78" /> <Output id="1400" points="2662 187" /> </Outputs> <Properties> <displayName>cGMP dissociates from CNG channels</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1027" reactomeId="2514867" points="2759 76, 2758 76, 2759 78" position="2758 76" lineWidth="1.0"> <Inputs> <Input id="1028" points="2733 44" /> <Input id="1029" points="2783 44" /> </Inputs> <Outputs> <Output id="1030" points="2709 102" /> <Output id="1031" points="2918 171" /> </Outputs> <Catalysts> <Catalyst id="1022" points="2783 76" /> </Catalysts> <Properties> <displayName>cGMP:CNG transports Na+ and Ca2+ into the rod outer segment</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1035" reactomeId="2514891" points="3108 305, 3107 304, 3107 305" position="3107 304" lineWidth="1.0"> <Inputs> <Input id="1036" points="3064 346" /> <Input id="1040" stoichiometry="4" points="3188 315" /> <Input id="1031" points="2964 207" /> </Inputs> <Outputs> <Output id="1037" points="3153 272" /> <Output id="1045" stoichiometry="4" points="3062 297" /> <Output id="1047" points="3187 357" /> </Outputs> <Catalysts> <Catalyst id="1038" points="3107 371" /> </Catalysts> <Properties> <displayName>SLC24A1 exchanges 4Na+ for Ca2+, K+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1075" reactomeId="2534096" points="1118 584, 1161 584, 1199 584" position="1161 584" lineWidth="1.0"> <Inputs> <Input id="1210" /> </Inputs> <Outputs> <Output id="1077" points="1228 602" /> <Output id="1078" points="1258 557" /> </Outputs> <Catalysts> <Catalyst id="1079" points="1160 610" /> </Catalysts> <Properties> <displayName>METAP1/2 demethylates GNAT1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1080" reactomeId="2534087" points="1343 505, 1374 496, 1412 496" position="1374 496" lineWidth="1.0"> <Inputs> <Input id="5824" points="1306 489" /> <Input id="1078" points="1322 515" /> </Inputs> <Outputs> <Output id="1082" points="1418 430" /> <Output id="1084" points="1461 481" /> </Outputs> <Catalysts> <Catalyst id="1097" points="1374 472" /> </Catalysts> <Properties> <displayName>NMT1/2 transfer MYS to GNAT1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1158" reactomeId="2534040" points="1408 573, 1438 573, 1568 573" position="1438 573" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="1078" points="1339 549" /> <Input id="1159" points="1370 583" /> </Inputs> <Outputs> <Output id="1161" points="1564 432" /> <Output id="1084" points="1505 491" /> </Outputs> <Catalysts> <Catalyst id="5821" points="1437 540" /> </Catalysts> <Properties> <displayName>Unknown NAT N-acylates Gly in GNAT1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1246" reactomeId="2530501" points="1114 449, 1140 449, 1168 449" position="1140 449" lineWidth="1.0"> <Inputs> <Input id="1247" points="1097 430" /> <Input id="1248" points="1102 456" /> </Inputs> <Outputs> <Output id="1249" points="1200 431" /> <Output id="1250" points="1185 467" /> </Outputs> <Catalysts> <Catalyst id="1251" points="1139 503" /> </Catalysts> <Properties> <displayName>FNTA:FNTB transfers FARN to GNGT1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1335" reactomeId="2581474" points="1838 417, 1885 417, 1919 417" position="1885 417" lineWidth="1.0"> <Inputs> <Input id="4938" stoichiometry="3" points="1814 432" /> <Input id="4913" points="1407 319, 1458 346" /> </Inputs> <Outputs> <Output id="4943" stoichiometry="3" points="1953 447" /> <Output id="4942" points="1963 418" /> </Outputs> <Catalysts> <Catalyst id="5142" points="1870 356" /> </Catalysts> <Inhibitors> <Inhibitor id="2605" points="1857 441" /> <Inhibitor id="1345" points="2188 432, 2135 500, 1959 500" /> <Inhibitor id="4610" points="1986 568" /> </Inhibitors> <Properties> <displayName>GRK1,4,7 phosphorylate MII to p-MII</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1343" reactomeId="2581488" points="2117 418, 2133 418, 2165 415" position="2133 418" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4942" points="2086 418" /> <Input id="1344" points="2085 459" /> </Inputs> <Outputs> <Output id="1345" /> </Outputs> <Properties> <displayName>SAG binds p-MII to form p-MII:SAG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1346" reactomeId="2632521" points="2251 417, 2264 417, 2264 417" position="2264 417" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="4910" points="2233 434" /> <Input id="1345" points="2237 415" /> </Inputs> <Outputs> <Output id="364" points="1744 441, 1856 526, 2245 530" /> <Output id="1347" points="2296 417" /> </Outputs> <Properties> <displayName>at-retinyl is hydrolysed from p-MII:SAG to release atRAL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1348" reactomeId="74947" points="2379 417, 2419 417, 2419 417" position="2419 417" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="1347" /> </Inputs> <Outputs> <Output id="1349" points="2458 417" /> <Output id="1344" points="2097 472, 2380 469" /> </Outputs> <Properties> <displayName>p-MII:SAG dissociates to p-RHO and SAG</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1353" reactomeId="74948" points="2622 418, 2652 418, 2693 418" position="2652 418" lineWidth="1.0"> <Inputs> <Input id="1349" points="2581 417" /> <Input id="1354" stoichiometry="3" points="2589 449" /> </Inputs> <Outputs> <Output id="350" points="1109 320, 1135 383, 2670 385" /> <Output id="1357" stoichiometry="3" points="2741 449" /> </Outputs> <Catalysts> <Catalyst id="1355" points="2652 519" /> </Catalysts> <Inhibitors> <Inhibitor id="1345" points="2198 432, 2188 503, 2575 503" /> </Inhibitors> <Activators> <Activator id="1359" points="2706 472" /> </Activators> <Properties> <displayName>PP2A dephosphorylates p-RHO to RHO</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1360" reactomeId="2584246" points="2235 306, 2271 306, 2246 263, 2043 263" position="2271 306" lineWidth="1.0"> <Inputs> <Input id="1019" points="2273 252" /> <Input id="1010" points="2193 306" /> </Inputs> <Outputs> <Output id="1365" points="2017 243" /> <Output id="1009" points="1959 294" /> <Output id="1362" points="2020 291" /> </Outputs> <Catalysts> <Catalyst id="1010" points="2188 322, 2272 335" /> </Catalysts> <Activators> <Activator id="1363" points="2301 306" /> </Activators> <Properties> <displayName>GNAT1-GTP hydrolyses its bound GTP to GDP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1381" reactomeId="74615" points="2372 265, 2449 266, 2503 266" position="2449 266" lineWidth="1.0"> <Inputs> <Input id="1363" points="2360 285" /> <Input id="1382" points="2360 255" /> </Inputs> <Outputs> <Output id="1383" points="2528 255" /> <Output id="1384" points="2529 284" /> </Outputs> <Catalysts> <Catalyst id="1385" points="2449 290" /> </Catalysts> <Properties> <displayName>PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1386" reactomeId="74882" points="1750 246, 1751 247, 1472 247, 1472 292" position="1751 247" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1005" points="1750 288" /> <Input id="1362" points="1993 291, 1911 246" /> </Inputs> <Outputs> <Output id="1000" /> </Outputs> <Properties> <displayName>GNAT1-GDP binds to GNB1:GNGT1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1387" reactomeId="2586748" points="2884 253, 2883 253, 2884 251, 2826 287" position="2884 251" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1388" points="2909 290" /> <Input id="1031" points="2929 207" /> </Inputs> <Outputs> <Output id="1389" /> </Outputs> <Properties> <displayName>GUCA binds Ca2+ to form GUCA:Ca2+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1390" reactomeId="74885" points="2784 257, 2726 257, 2676 257" position="2726 257" lineWidth="1.0"> <Inputs> <Input id="1393" /> </Inputs> <Outputs> <Output id="1395" points="2644 257" /> <Output id="1400" points="2644 214" /> </Outputs> <Catalysts> <Catalyst id="1391" points="2727 287" /> </Catalysts> <Inhibitors> <Inhibitor id="1389" points="2791 287" /> <Inhibitor id="5476" points="2794 198" /> <Inhibitor id="5477" points="2809 226" /> </Inhibitors> <Activators> <Activator id="5474" points="2703 237" /> <Activator id="5475" points="2729 210" /> </Activators> <Properties> <displayName>GUCYs converts GTP to cGMP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1406" reactomeId="74031" points="2899 125, 2897 125, 2860 91" position="2897 125" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1023" points="3008 93" /> <Input id="1400" points="2662 189" /> </Inputs> <Outputs> <Output id="1022" /> </Outputs> <Properties> <displayName>cGMP binds CNG channel to form cGMP:CNG channel</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4601" reactomeId="3229181" points="3081 128, 3108 155, 3108 193" position="3108 155" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1023" points="3051 93" /> <Input id="5146" points="3052 128" /> </Inputs> <Outputs> <Output id="4603" /> </Outputs> <Activators> <Activator id="1031" points="2971 183" /> </Activators> <Properties> <displayName>CALM1:Ca2+ binds CNG channel</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4608" reactomeId="3229213" points="1919 559, 1918 560, 1951 572" position="1918 560" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="4609" points="1892 554" /> <Input id="1339" points="1894 513" /> </Inputs> <Outputs> <Output id="4610" /> </Outputs> <Properties> <displayName>RCVRN:Ca2+ binds to and inhibits GRK1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4876" reactomeId="2466846" points="1505 754, 1505 788, 1505 835" position="1505 788" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="2603" points="1527 721" /> <Input id="741" points="1484 722" /> </Inputs> <Outputs> <Output id="651" /> </Outputs> <Properties> <displayName>atRAL can spontaneously react with PE to form NRPE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4878" reactomeId="2466764" points="1429 785, 1370 785, 1326 785" position="1370 785" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="651" points="1488 835" /> <Input id="741" points="1466 722" /> </Inputs> <Outputs> <Output id="736" points="1249 836" /> <Output id="737" points="1270 771" /> </Outputs> <Properties> <displayName>NRPE condenses with atRAL to form A2PE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4888" reactomeId="2466831" points="1193 796, 1156 796, 1114 796" position="1156 796" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="736" points="1218 836" /> <Input id="737" points="1221 778" /> </Inputs> <Outputs> <Output id="4890" points="1095 780" /> <Output id="4891" points="1075 833" /> </Outputs> <Catalysts> <Catalyst id="764" points="1155 839" /> </Catalysts> <Properties> <displayName>A2PE hydrolyses to A2E</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4906" reactomeId="2467761" points="1068 869, 1078 886, 1099 903" position="1078 886" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="4891" /> </Inputs> <Outputs> <Output id="778" /> </Outputs> <Properties> <displayName>A2E is phagocytosed</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4907" reactomeId="2467738" points="1092 921, 958 921, 892 800" position="958 921" lineWidth="1.0" isForDisease="true" lineColor="255 0 0"> <Inputs> <Input id="778" /> </Inputs> <Outputs> <Output id="780" /> </Outputs> <Properties> <displayName>A2E translocates to RPE cells</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5129" reactomeId="6786239" points="476 582, 522 582, 563 582" position="522 582" lineWidth="1.0"> <Inputs> <Input id="5130" points="418 582" /> <Input id="5135" points="427 612" /> <Input id="5137" points="461 610" /> <Input id="5139" points="464 571" /> </Inputs> <Outputs> <Output id="5131" points="605 583" /> <Output id="5132" points="584 565" /> <Output id="5141" points="587 607" /> </Outputs> <Catalysts> <Catalyst id="5133" points="521 541" /> </Catalysts> <Properties> <displayName>CYP4V2 omega-hydroxylates DHA to HDoHE</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="5143" points="1887 485, 1869 356" position="1878 420" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1339" /> </Inputs> <Outputs> <Output id="5142" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="5144" reactomeId="74448" points="3009 206, 3008 206, 2999 143" position="3008 206" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1031" stoichiometry="4" points="2971 195" /> <Input id="5472" points="3012 531" /> </Inputs> <Outputs> <Output id="5146" /> </Outputs> <Properties> <displayName>Calcium binds calmodulin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5192" reactomeId="6786205" points="2965 560, 2910 560, 2865 560" position="2910 560" lineWidth="1.0"> <Inputs> <Input id="5472" points="2985 552" /> <Input id="5193" stoichiometry="3" points="2987 588" /> </Inputs> <Outputs> <Output id="5194" stoichiometry="3" points="2843 603" /> <Output id="5473" points="2832 560" /> </Outputs> <Catalysts> <Catalyst id="5196" points="2910 517" /> </Catalysts> <Properties> <displayName>KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="5198" interactionType="Activate" points="143 882, 179 882" position="161 882" lineWidth="2.0"> <Inputs> <Input id="5197" /> </Inputs> <Outputs> <Output id="246" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="5392" reactomeId="8960973" points="797 192, 851 218, 849 216" position="851 218" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="320" /> </Inputs> <Outputs> <Output id="5387" points="886 216" /> <Output id="2526" points="365 128, 365 85, 819 85" /> </Outputs> <Properties> <displayName>RLBP1:11cRAL dissociates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5469" reactomeId="8981410" points="396 1215, 396 1252, 396 1291" position="396 1252" lineWidth="1.0"> <Inputs> <Input id="5467" /> </Inputs> <Outputs> <Output id="536" points="501 1291" /> <Output id="5471" points="372 1314" /> </Outputs> <Properties> <displayName>11cRPALM dissociates</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="5479" points="1340 1226, 1396 1177" position="1368 1201" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="5478" /> </Inputs> <Outputs> <Output id="580" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="5481" points="1479 1190, 1434 1177" position="1456 1183" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="5480" /> </Inputs> <Outputs> <Output id="580" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="5483" points="1425 1214, 1411 1177" position="1418 1195" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="5482" /> </Inputs> <Outputs> <Output id="580" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="5486" points="1700 1273, 1759 1271" position="1729 1272" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="5485" /> </Inputs> <Outputs> <Output id="581" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="5488" points="1683 1297, 1759 1280" position="1721 1288" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="5487" /> </Inputs> <Outputs> <Output id="581" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="5490" points="1701 1250, 1759 1260" position="1730 1255" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="5489" /> </Inputs> <Outputs> <Output id="581" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="5798" reactomeId="9656891" points="1458 1307, 1479 1315, 1492 1295" position="1479 1315" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5480" points="1505 1212" /> <Input id="5466" points="1319 1287" /> </Inputs> <Outputs> <Output id="5487" points="1585 1305" /> <Output id="5528" points="1512 1311" /> </Outputs> <Properties> <displayName>OPN1SW binds 11cRAL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5800" reactomeId="9656893" points="1398 1269, 1469 1253, 1523 1268" position="1469 1253" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="5478" points="1355 1254" /> <Input id="5466" points="1319 1279" /> </Inputs> <Outputs> <Output id="5489" points="1592 1255" /> <Output id="5528" points="1526 1311" /> </Outputs> <Properties> <displayName>OPN1MW binds 11cRAL</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5808" reactomeId="74101" points="1317 306, 1328 306, 1339 305" position="1328 306" lineWidth="1.0"> <Inputs> <Input id="4911" points="1307 306" /> <Input id="5810" points="1316 46" /> </Inputs> <Outputs> <Output id="4913" /> </Outputs> <Properties> <displayName>Photons induce isomerization of 11c-retinyl to at-retinyl</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process> |
| width | 3242 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Diagram of Visual phototransduction, Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D), Biosynthesis of A2E, implicated in retinal degradation, Defective visual phototransduction due to ABCA4 loss of function, Defective visual phototransduction due to LRAT loss of function, Defective visual phototransduction due to OPN1LW loss of function, Defective visual phototransduction due to OPN1MW loss of function, Defective visual phototransduction due to OPN1SW loss of function, Defective visual phototransduction due to RDH12 loss of function, Defective visual phototransduction due to RDH5 loss of function, and Defective visual phototransduction due to STRA6 loss of function (2468358)
