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Details on Person Several agrin (AGRN) ligands require the presence of heparan...

Class:Id	Summation:2467672
_displayName	Several agrin (AGRN) ligands require the presence of heparan...
_timestamp	2012-12-19 17:27:11
created	[InstanceEdit:2467678] Jupe, S, 2012-09-13
literatureReference	[LiteratureReference:2467679] Agrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchyma [LiteratureReference:2467682] Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain [LiteratureReference:2467661] Agrin binds alpha-synuclein and modulates alpha-synuclein fibrillation [LiteratureReference:2467666] The role of an agrin-growth factor interaction in ACh receptor clustering [LiteratureReference:2467667] Identification of extracellular matrix ligands for the heparan sulfate proteoglycan agrin
modified	[InstanceEdit:2867920] Jupe, S, 2012-12-19
text	Several agrin (AGRN) ligands require the presence of heparan-sulfate GAG sidechains and probably represent interactions with them. Extracellular ligands include Beta-amyloid (Donahue et al. 1999, Cotman et al. 2000). Other ligands (unconfirmed in humans) include alpha-synuclein fibrils (chicken - Liu et al. 2005), HB-GAM/pleiotropin (Dagget et al. 1996), thrombospondin and FGF2 (Cotman et al. 1999).
(summation)	[Reaction:2467665] AGRN binds Beta amyloid fibril via GAG chains [Homo sapiens]
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