Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The outer segment of photoreceptor cells is shed every 10-14...
| Class:Id | Summation:2466784 |
|---|---|
| _displayName | The outer segment of photoreceptor cells is shed every 10-14... |
| _timestamp | 2012-09-13 08:47:21 |
| created | [InstanceEdit:2466812] Jassal, Bijay, 2012-09-12 |
| modified | [InstanceEdit:2467455] Jassal, B, 2012-09-13 |
| text | The outer segment of photoreceptor cells is shed every 10-14 days to be completely replaced. The shed material is phagocytosed and transferred to the retinal pigment epithelium (RPE). Diretinoid-pyridinium-phosphatidylethanolamine (A2PE) can be hydrolysed to diretinoid-pyridinium-ethanolamine (A2E), a prominent constituent of lipofuscin (the material deposited in retinal tissue which accumulates over time and is implicated in macular degeneration). Evidence suggests this happens before transfer to RPE cells as part of the phagocytosed outer segment. A2E has been detected in outer segments (Ben-Shabat et al. 2002) and an N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPEPLD) activity detected in rat, mouse and human proteins (Okamoto et al. 2004, Ueda et al. 2005, Wang et al. 2006). This activity has been shown to hydrolyse A2PE to A2E in bovine outer segments before phagocytosis and transfer to RPE cells, suggesting A2PE is hydrolysed to A2E in photoreceptor outer segment membranes (Sparrow et al. 2003, Salvador & Giusto 1998). |
| (summation) | [Reaction:2466831] A2PE hydrolyses to A2E [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The outer segment of photoreceptor cells is shed every 10-14... (2466784)
