Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Biglycan (BGN) is a member of the small leucine-rich repeat ...

Class:IdSummation:2466126
_displayNameBiglycan (BGN) is a member of the small leucine-rich repeat ...
_timestamp2012-12-19 17:24:37
created[InstanceEdit:2466194] Jupe, S, 2012-09-06
literatureReference[LiteratureReference:2466220] Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues
[LiteratureReference:2466155] Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
[LiteratureReference:2466236] Interaction of biglycan with type I collagen
[LiteratureReference:2466199] The interactions of cartilage proteoglycans with collagens are determined by their structures
[LiteratureReference:2466165] Biglycan and decorin bind close to the n-terminal region of the collagen VI triple helix
[LiteratureReference:2466201] Interactions between collagen IX and biglycan measured by atomic force microscopy
[LiteratureReference:2466190] Influence of collagen-fibril-based coatings containing decorin and biglycan on osteoblast behavior
modified[InstanceEdit:2867920] Jupe, S, 2012-12-19
textBiglycan (BGN) is a member of the small leucine-rich repeat proteoglycan family (SLRPs) which also includes decorin, fibromodulin (Hedlund et al. 1994 - binding to collagen II), lumican and asporin (Hedbom & Heinegard 1993, Ezura et al. 2000). All appear to be involved in collagen fibril formation and matrix assembly (Ameye & Young 2002).

BGN-deficient mice exhibit larger and irregular fibrils leading to thin dermis and reduced bone mass (Corsi et al. 2002, Xu et al. 1998). BGN binds collagen types I (Schönherr et al. 1995), II (Bovine, using pig BGN - Vynios et al. 2001, Bovine, using bovine BGN - Douglas et al. 2008), III (Bovine, using bovine BGN - Douglas et al. 2008), VI (Wiberg et al. 2001) and IX (Chen et al. 2006 - species source of collagen/BGN unknown).
(summation)[Reaction:2466238] BGN binds Collagen types II, III [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Biglycan (BGN) is a member of the small leucine-rich repeat ... (2466126)
Follow Reactome