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Details on Person Sulfated glycolipids (SGs) such as the sulfatides bind stron...

Class:IdSummation:2465900
_displayNameSulfated glycolipids (SGs) such as the sulfatides bind stron...
_timestamp2013-07-31 15:05:20
created[InstanceEdit:2465853] Jupe, S, 2012-09-04
literatureReference[LiteratureReference:2465903] Laminin binds specifically to sulfated glycolipids
[LiteratureReference:2465836] Comparison of the specificities of laminin, thrombospondin, and von Willebrand factor for binding to sulfated glycolipids
[LiteratureReference:2328102] Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins
[LiteratureReference:4084513] Crystal structure and cell surface anchorage sites of laminin alpha1LG4-5
[LiteratureReference:2465895] Chemistry and functional distribution of sulfoglycolipids
[LiteratureReference:2465891] 04 and A007-sulfatide antibodies bind to embryonic Schwann cells prior to the appearance of galactocerebroside; regulation of the antigen by axon-Schwann cell signals and cyclic AMP
[LiteratureReference:2396028] Laminin-sulfatide binding initiates basement membrane assembly and enables receptor signaling in Schwann cells and fibroblasts
[LiteratureReference:1592404] Developmental and pathogenic mechanisms of basement membrane assembly
modified[InstanceEdit:4084534] Jupe, S, 2013-07-29
[InstanceEdit:4084738] Jupe, S, 2013-07-31
textSulfated glycolipids (SGs) such as the sulfatides bind strongly to LG domains 4-5 of laminin (Roberts et al. 1985,1986, Ishizuka 1997, Talts et al. 1999, Harrison et al. 2007). The most common sulfated glycolipid HSO3-3galactosylBeta-1ceramide (galactosyl-3-sulfate ceramide or sulfatide) is highly expressed in developing and adult peripheral nerves (Mirsky et al. 1990), Schwann cells, kidney and other tissues. SGs are thought to mediate or enhance the cell surface anchorage of laminins, possibly by allowing the short arms to bind the cell surface in addition to the LG domains (Li et al. 2005, Yurchenko & Patton 2009).
(summation)[Reaction:2465886] Laminin binds galactosyl sulfatide and related sulfated glycolipids [Mus musculus]
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