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Details on Person UniProt:Q96T23 RSF1
| Class:Id | ReferenceGeneProduct:246585 |
|---|---|
| _chainChangeLog | chain:1-1441 added on Fri February 6 2015 |
| _displayName | UniProt:Q96T23 RSF1 |
| _timestamp | 2026-02-20 22:48:42 |
| chain | chain:1-1441 |
| checksum | 0FCB9499B5097A2F |
| comment | FUNCTION Regulatory subunit of the ATP-dependent RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:12972596, PubMed:28801535). Binds to core histones together with SMARCA5, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex (PubMed:12972596). Directly stimulates the ATPase activity of SMARCA1 and SMARCA5 in the RSF-1 and RSF-5 ISWI chromatin-remodeling complexes, respectively (PubMed:28801535). The RSF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the RSF-5 ISWI chromatin-remodeling complex (PubMed:28801535). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain (PubMed:11788598, PubMed:11944984).SUBUNIT Component of the RSF-1 ISWI chromatin-remodeling complex at least composed of SMARCA1 and RSF1 (PubMed:28801535). Within the RSF-1 ISWI chromatin-remodeling complex interacts with SMARCA1 (PubMed:28801535). Component of the RSF-5 ISWI chromatin-remodeling complex (also called the RSF complex) at least composed of SMARCA5/SNF2H and RSF1 (PubMed:12972596, PubMed:28801535). Within the RSF-5 ISWI chromatin-remodeling complex interacts with SMARCA5/SNF2H; the interaction is direct (PubMed:12972596, PubMed:28801535). Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292). Also binds the HBV pX/HBx protein, which is required to activate transcription of the viral genome (PubMed:11788598, PubMed:11944984).INTERACTION Localization is diffuse during mitosis (PubMed:12972596). Co-localizes with SMARCA5 in the nucleus (PubMed:12972596).ALTERNATIVE PRODUCTS Experimental confirmation may be lacking for some isoforms.TISSUE SPECIFICITY Ubiquitously expressed. Highly expressed in the heart, skeletal muscle, kidney and placenta (PubMed:12972596). Expressed at low levels in the brain and colon (PubMed:12972596).PTM Phosphorylated.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Remodeling and spacing factor 1 shortName: Rsf-1 alternativeName: HBV pX-associated protein 8 alternativeName: Hepatitis B virus X-associated protein alternativeName: p325 subunit of RSF chromatin-remodeling complex |
| geneName | RSF1 HBXAP XAP8 |
| identifier | Q96T23 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Chromatin regulator Coiled coil Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | RSF1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003213] ENSEMBL:ENSG00000048649 RSF1 [Homo sapiens] |
| secondaryIdentifier | RSF1_HUMAN Q86X86 Q9H3L8 Q9NVZ8 Q9NYU0 |
| sequenceLength | 1441 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:246586] UniProt:Q96T23-2 RSF1 [Homo sapiens] [ReferenceIsoform:246587] UniProt:Q96T23-3 RSF1 [Homo sapiens] [ReferenceIsoform:413117] UniProt:Q96T23-1 RSF1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:606345] RSF1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96T23 RSF1 (246585)
