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Details on Person UniProt:Q8K202 Polr1e
| Class:Id | ReferenceGeneProduct:246361 |
|---|---|
| _chainChangeLog | chain:1-482 added on Fri February 6 2015 |
| _displayName | UniProt:Q8K202 Polr1e |
| _timestamp | 2024-05-14 17:38:51 |
| chain | chain:1-482 |
| checksum | 4237E14E1B90BB31 |
| comment | FUNCTION Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates (PubMed:8641287, PubMed:9254723). Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:8641287).SUBUNIT Component of the RNA polymerase I (Pol I) complex consisting of 13 subunits: a ten-subunit catalytic core composed of POLR1A/RPA1, POLR1B/RPA2, POLR1C/RPAC1, POLR1D/RPAC2, POLR1H/RPA12, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk subunit POLR1F/RPA43 protruding from the core and additional subunits homologous to general transcription factors POLR1E/RPA49 and POLR1G/RPA34. Forms a heterodimer with POLR1G/RPA34 (PubMed:9254723). Interacts with POLR1G (PubMed:15226435). Also binds UBTF/UBF (PubMed:8641287). Interacts with PWP1 (By similarity).SUBCELLULAR LOCATION Acetylated at Lys-436 by CREBBP/CBP, leading to decreased RNA polymerase I transcription. In normal conditions, deacetylated by SIRT7, promoting the association of RNA polymerase I with the rDNA promoter region and coding region. In response to stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased association of RNA polymerase I with the rDNA promoter region.SIMILARITY Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: DNA-directed RNA polymerase I subunit RPA49 shortName: RNA polymerase I subunit A49 alternativeName: DNA-directed RNA polymerase I subunit E alternativeName: RNA polymerase I-associated factor 1 alternativeName: RNA polymerase I-associated factor 53 |
| geneName | Polr1e Paf53 Praf1 |
| identifier | Q8K202 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Direct protein sequencing DNA-directed RNA polymerase Nucleus Phosphoprotein Reference proteome Transcription |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 |
| name | Polr1e |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RPA49_MOUSE B1AXQ6 B1AXQ7 Q62034 Q8BQG9 |
| sequenceLength | 482 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:246362] UniProt:Q8K202-2 Polr1e [Mus musculus] [ReferenceIsoform:246363] UniProt:Q8K202-3 Polr1e [Mus musculus] [ReferenceIsoform:411039] UniProt:Q8K202-1 Polr1e [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:73710] p53 - RNA Pol I associated factor [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q8K202 Polr1e (246361)
