Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person UniProt:Q9GZS1 POLR1E

Class:IdReferenceGeneProduct:246359
_chainChangeLogchain:1-481 added on Fri February 6 2015;chain:1-481 for 246359 removed on Fri February 15 2019;chain:1-419 for 246359 added on Fri February 15 2019
_displayNameUniProt:Q9GZS1 POLR1E
_timestamp2024-11-03 19:58:21
chainchain:1-419
checksumAB9EF3B9E8230053
commentFUNCTION Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates (PubMed:24207024, PubMed:34671025, PubMed:34887565, PubMed:36271492). Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:24207024).SUBUNIT Component of the RNA polymerase I (Pol I) complex consisting of 13 subunits: a ten-subunit catalytic core composed of POLR1A/RPA1, POLR1B/RPA2, POLR1C/RPAC1, POLR1D/RPAC2, POLR1H/RPA12, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk subunit POLR1F/RPA43 protruding from the core and additional subunits homologous to general transcription factors POLR1E/RPA49 and POLR1G/RPA34 (PubMed:16809778, PubMed:29065309, PubMed:34671025, PubMed:34887565, PubMed:36271492). Forms a heterodimer with POLR1G/RPA34 (PubMed:36271492). Interacts with POLR1G (By similarity). Also binds UBTF/UBF (By similarity). Interacts with PWP1 (PubMed:29065309).INTERACTION Acetylated at Lys-373 by CREBBP/CBP, leading to decreased RNA polymerase I transcription (PubMed:24207024). In normal conditions, deacetylated by SIRT7, promoting the association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). In response to stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased association of RNA polymerase I with the rDNA promoter region (PubMed:24207024).MISCELLANEOUS Dubious isoform produced through intron retention.SIMILARITY Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
created[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
descriptionrecommendedName: DNA-directed RNA polymerase I subunit RPA49 shortName: RNA polymerase I subunit A49 alternativeName: DNA-directed RNA polymerase I subunit E alternativeName: RNA polymerase I-associated factor 1 alternativeName: fullName evidence="11"RNA polymerase I-associated factor 53
geneNamePOLR1E
PAF53
PRAF1
identifierQ9GZS1
isSequenceChangedFALSE
keyword3D-structure
Acetylation
Alternative splicing
DNA-directed RNA polymerase
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transcription
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9909836] Weiser, Joel, 2024-05-14
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
namePOLR1E
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8989783] ENSEMBL:ENSG00000137054 POLR1E [Homo sapiens]
secondaryIdentifierRPA49_HUMAN
Q5VZT3
Q8NBA9
Q96L20
sequenceLength419
species[Species:48887] Homo sapiens
(isoformParent)[ReferenceIsoform:246360] UniProt:Q9GZS1-2 POLR1E [Homo sapiens]
[ReferenceIsoform:414108] UniProt:Q9GZS1-1 POLR1E [Homo sapiens]
(referenceEntity)[EntityWithAccessionedSequence:5419294] POLR1E [nucleoplasm] [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by UniProt:Q9GZS1 POLR1E (246359)
Follow Reactome