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Details on Person UniProt:Q9ESG2 Ropn1
| Class:Id | ReferenceGeneProduct:246340 |
|---|---|
| _chainChangeLog | chain:1-212 added on Fri February 6 2015 |
| _displayName | UniProt:Q9ESG2 Ropn1 |
| _timestamp | 2026-02-20 21:43:49 |
| chain | chain:1-212 |
| checksum | 782EA4C6890BC50C |
| comment | FUNCTION Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.SUBUNIT Homodimer. Interacts with AKAP3 (By similarity). May interact with SPA17 (By similarity). Interacts with RHPN1 (PubMed:10591629). Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (PubMed:27398160). Interacts with CFAP61 (PubMed:34792097).INTERACTION In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath.TISSUE SPECIFICITY Testis-specific. Present in the most inner parts of seminiferous tubules (at protein level).DEVELOPMENTAL STAGE Expression in testis starts at P21, and increases to reach a plateau at P27 (PubMed:10591629). Expressed in the flagella of sperm at all stages of development in the testis and epididymis (PubMed:23303679).DOMAIN The RIIa domain mediates interaction with AKAP3.PTM Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.DISRUPTION PHENOTYPE Mutant mice are subfertile with normal testicular morphology and spermatogenesis but moderately impaired motility and increased levels of ROPN1L (PubMed:23303679). Double knockout animals for ROPN1 and ROPN1L are infertile with normal testicular morphology and spermatogenesis but defects in sperm morphology, thinning and shredding of the principal piece. Sperm is immotile (PubMed:23303679).MISCELLANEOUS 'Ropporin' comes from the Japanese word 'oppo' which means 'tail'.SIMILARITY Belongs to the ropporin family. |
| created | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 |
| description | recommendedName: Ropporin-1 alternativeName: Rhophilin-associated 'oppo' protein alternativeName: Rhophilin-associated protein 1 |
| geneName | Ropn1 |
| identifier | Q9ESG2 |
| isSequenceChanged | FALSE |
| keyword | Cell projection Cilium Flagellum Phosphoprotein Reference proteome Ubl conjugation |
| modified | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Ropn1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ROP1_MOUSE Q3TVG5 |
| sequenceLength | 212 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:5667046] Ropn1 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q9ESG2 Ropn1 (246340)
